Carvedilol reverses hyperthermia and attenuates rhabdomyolysis induced by 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy) in an animal model*
Jon E. Sprague, Petra Moze, David Caden, Daniel E. Rusyniak, Courtney Holmes, David S. Goldstein, Edward Mills
Critical Care Medicine June 1, 2005 DOI: 10.1097/01.ccm.0000165969.29002.70 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Preclinical study Peer reviewed |
|---|---|
| Topics | MDMA |
| Keywords | Hyperthermia Carvedilol Pharmacology Rhabdomyolysis Nadolol Catecholamine Adrenergic antagonist Rasagiline Hypothermia Anesthesia Citalopram Propranolol Endocrinology |
| Citations | 75 |
| Key points | Alpha1 and beta3-adrenergic receptors may contribute to MDMA-induced hyperthermia, and drugs targeting these receptors, such as carvedilol, warrant further investigation as treatments. |
Abstract
These data show that alpha1 and beta3-adrenergic receptors may contribute to the mediation of MDMA-induced hyperthermia and that drugs targeting these receptors, such as carvedilol, warrant further investigation as novel therapies for the treatment of psychostimulant-induced hyperthermia and its sequelae.
Comparable studies
Other preclinical and animal studies on MDMA, most cited first.
Citations in the library
Cited by 29
- The Norepinephrine Transporter Inhibitor Reboxetine Reduces Stimulant Effects of MDMA (“Ecstasy”) in Humans Clinical Pharmacology & Therapeutics June 15, 2011
- Pharmacology and Toxicology of N-Benzylphenethylamine ("NBOMe") Hallucinogens. Current Topics in Behavioral Neurosciences 2017
- The role of monoamines in the changes in body temperature induced by 3,4‐methylenedioxymethamphetamine (MDMA, ecstasy) and its derivatives British Journal of Pharmacology March 3, 2010
- Carvedilol inhibits the cardiostimulant and thermogenic effects of MDMA in humans British Journal of Pharmacology March 8, 2012
- Effects of MDMA on body temperature in humans Temperature October 31, 2014
and 24 more in the library
Cites 9
- Stereochemical effects of 3,4-methylenedioxymethamphetamine (MDMA) and related amphetamine derivatives on inhibition of uptake of [3H]monoamines into synaptosomes from different regions of rat brain. Biochemical Pharmacology July 15, 1987
- Cutaneous Vasoconstriction Contributes to Hyperthermia Induced by 3,4-Methylenedioxymethamphetamine (Ecstasy) in Conscious Rabbits Journal of Neuroscience November 1, 2001
- Attenuation of 3,4‐methylenedioxymethamphetamine (MDMA, Ecstasy)‐induced rhabdomyolysis with α1‐ plus β3‐adrenoreceptor antagonists British Journal of Pharmacology June 1, 2004
- A Fatal Trip with Ecstasy: A Case of 3,4-Methylene-Dioxymethamphetamine/ 3,4-Methylenedioxy-Amphetamine Toxicity Journal of the Royal Society of Medicine 1996
- Induction of malignant hyperthermia in susceptible swine by 3,4-methylenedioxymethamphetamine ("ecstasy"). Anesthesiology November 2003
and 4 more in the library