Acute Psychological and Neurophysiological Effects of MDMA in Humans
Franz X. Vollenweider, Matthias E. Liechti, Alex Gamma, George Greer, Mark A. Geyer
Journal of Psychoactive Drugs June 1, 2002 DOI: 10.1080/02791072.2002.10399951 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Review Placebo-controlled Peer reviewed |
|---|---|
| Population | Healthy human volunteers |
| Intervention | MDMA |
| Topics | MDMA |
| Keywords | Recreational drug Recreational use Neuropsychology Cognition Hallucinogen |
| Citations | 92 |
| Key findings | MDMA produces acute effects on psychological and cognitive measures, information processing, and regional brain activity in healthy human volunteers. |
Abstract
Since the mid 1990s, MDMA has been increasingly used as a recreational drug called "Ecstasy" by young people in Europe and the United States. However, despite the widespread recreational use of Ecstasy, systematic data on the psychological and neurobiological effects of MDMA have been scant. To further our understanding of the mechanism of action of MDMA, the authors conducted several studies in healthy human volunteers in an effort to characterize the psychological, cognitive and behavioral effects of MDMA in healthy human volunteers. Prospective placebo-controlled within-subject study designs and standardized psychometric ratings and neuropsychological tests were used to assess the acute, short-term and prolonged effects of the drug. To elucidate the role of various neurotransmitter and receptor systems involved in the action of MDMA in humans, the blocking effects of specific receptor antagonists on MDMA-induced psychological alterations and measures of sensory information processing were studied. To identify the functional neuroanatomy involved in the action of MDMA, Positron Emission Tomography (PET) was used. The present contribution summarizes the acute effect of MDMA on psychological and cognitive measures, information processing, and regional brain activity in healthy human volunteers.
Comparable studies
Other narrative reviews on MDMA, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Human Pharmacology of MDMA | 2004 | Review | |
| Human psychopharmacology of Ecstasy (MDMA): a review of 15 years of empirical research | 2001 | Review | |
| 3,4‐Methylenedioxymethamphetamine (MDMA, “Ecstasy”): pharmacology and toxicology in animals and humans | 1994 | Review | |
| (±)3,4-Methylenedioxymethamphetamine (‘Ecstasy’)-Induced Serotonin Neurotoxicity: Studies in Animals | 2000 | Review | |
| Amphetamine toxicities | 2010 | Review |
Citations in the library
Cited by 40
- Increased oxytocin concentrations and prosocial feelings in humans after ecstasy (3,4-methylenedioxymethamphetamine) administration Social Neuroscience June 25, 2009
- Psychedelics in Psychiatry: Neuroplastic, Immunomodulatory, and Neurotransmitter Mechanisms Pharmacological Reviews December 16, 2020
- A review of acute effects of 3,4-methylenedioxymethamphetamine in healthy volunteers Journal of Psychopharmacology March 1, 2006
- MDMA in humans: factors which affect the neuropsychobiological profiles of recreational ecstasy users, the integrative role of bioenergetic stress Journal of Psychopharmacology March 1, 2006
- 3,4-Methylenedioxymethamphetamine facilitates fear extinction learning Translational Psychiatry September 15, 2015
and 35 more in the library
Cites 47
- Psilocybin induces schizophrenia-like psychosis in humans via a serotonin-2 agonist action Neuroreport December 1, 1998
- Amphetamine-type central nervous system stimulants release norepinephrine more potently than they release dopamine and serotonin Synapse 2000
- Evidence for 5-HT2 involvement in the mechanism of action of hallucinogenic agents. Life Sciences December 17, 1984
- The Standardized Psychometric Assessment of Altered States of Consciousness (ASCs) in Humans Pharmacopsychiatry July 1, 1998
- Differences Between the Mechanism of Action of MDMA, MBDB, and the Classic Hallucinogens. Identification of a New Therapeutic Class: Entactogens Journal of Psychoactive Drugs October 1, 1986
and 42 more in the library