Psychedelic-induced mystical experiences: An interdisciplinary discussion and critique
Sharday Mosurinjohn, Leor Roseman, Manesh Girn
Frontiers in Psychiatry April 5, 2023 DOI: 10.3389/fpsyt.2023.1077311 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Theoretical or philosophical paper Peer reviewed |
|---|---|
| Topics | Mysticism Mystical experience |
| Keywords | Psychotherapist Psychoanalysis Epistemology Engineering ethics |
| Citations | 54 |
| Key points | Argues that the operationalization of 'mystical experiences' in psychedelic research is historically biased and insufficiently contextualized, and proposes more culturally-sensitive and non-mystical approaches. |
Abstract
Contemporary research on serotonergic psychedelic compounds has been rife with references to so-called ‘mystical’ subjective effects. Several psychometric assessments have been used to assess such effects, and clinical studies have found quantitative associations between ‘mystical experiences’ and positive mental health outcomes. The nascent study of psychedelic-induced mystical experiences, however, has only minimally intersected with relevant contemporary scholarship from disciplines within the social sciences and humanities, such as religious studies and anthropology. Viewed from the perspective of these disciplines—which feature rich historical and cultural literatures on mysticism, religion, and related topics—‘mysticism’ as used in psychedelic research is fraught with limitations and intrinsic biases that are seldom acknowledged. Most notably, existing operationalizations of mystical experiences in psychedelic science fail to historicize the concept and therefore fail to acknowledge its perennialist and specifically Christian bias. Here, we trace the historical genesis of the mystical in psychedelic research in order to illuminate such biases, and also offer suggestions toward more nuanced and culturally-sensitive operationalizations of this phenomenon. In addition, we argue for the value of, and outline, complementary ‘non-mystical’ approaches to understanding putative mystical-type phenomena that may help facilitate empirical investigation and create linkages to existing neuro-psychological constructs. It is our hope that the present paper helps build interdisciplinary bridges that motivate fruitful paths toward stronger theoretical and empirical approaches in the study of psychedelic-induced mystical experiences.
Comparable studies
Other theoretical and historical papers on mystical experience, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Religious and Mystical Experiences as Artifacts of Temporal Lobe Function: A General Hypothesis | 1983 | Theoretical or philosophical paper | |
| The Psychedelic Mystical Experience in the Human Encounter with Death | 1969 | Theoretical or philosophical paper | |
| Vectorial Cerebral Hemisphericity as Differential Sources for the Sensed Presence, Mystical Experiences and Religious Conversions | 1993 | Theoretical or philosophical paper | |
| The epistemic innocence of psychedelic states. | 2016 | Theoretical or philosophical paper | |
| Mystical Experience and Religious Doctrine | 1982 | Theoretical or philosophical paper |
Citations in the library
Cited by 47
- 5-MeO-DMT for post-traumatic stress disorder: a real-world longitudinal case study Frontiers in Psychiatry November 23, 2023
- Classification schemes of altered states of consciousness. Neuroscience & Biobehavioral Reviews August 1, 2025
- Historians on Drugs: Toward an Empirical Historiography of Global Psychedelic Cultures South Atlantic Quarterly April 1, 2025
- From Efficacy to Effectiveness: Evaluating Psychedelic Randomized Controlled Trials for Trustworthy Evidence‐Based Policy and Practice Pharmacology Research & Perspectives April 1, 2025
- Psychedelics as a potential treatment for tobacco use disorder: a systematic review. Discover Mental Health September 17, 2024
and 42 more in the library
Cites 49
- Psilocybin produces substantial and sustained decreases in depression and anxiety in patients with life-threatening cancer: A randomized double-blind trial Journal of Psychopharmacology November 30, 2016
- Rapid and sustained symptom reduction following psilocybin treatment for anxiety and depression in patients with life-threatening cancer: a randomized controlled trial Journal of Psychopharmacology November 30, 2016
- Psilocybin can occasion mystical-type experiences having substantial and sustained personal meaning and spiritual significance Psychopharmacology July 7, 2006
- Psilocybin with psychological support for treatment-resistant depression: an open-label feasibility study. The Lancet Psychiatry May 17, 2016
- Trial of Psilocybin versus Escitalopram for Depression New England Journal of Medicine April 14, 2021
and 44 more in the library