Systems-level analysis of local field potentials reveals differential effects of lysergic acid diethylamide and ketamine on neuronal activity and functional connectivity.
Azat Nasretdinov, Sebastian A Barrientos, Ivani Brys, Pär Halje, Per Petersson
Frontiers in Neuroscience 2023 DOI: 10.3389/fnins.2023.1175575 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Animal study Peer reviewed |
|---|---|
| Population | Rodents |
| Interventions | LSD ketamine |
| Topics | Esketamine Ketamine LSD |
| Keywords | Lfp Dissociative anesthetics In vivo Neurophysiology Psychedelics Psychopharmacology Consciousness research Brain connectivity Psychedelic medicine |
| Citations | 6 |
| Key points | LSD and ketamine both reduce brain connectivity, but only ketamine increases neuronal activity as measured by LFP power shifts. |
Abstract
Psychedelic substances have in recent years attracted considerable interest as potential treatments for several psychiatric conditions, including depression, anxiety, and addiction. Imaging studies in humans point to a number of possible mechanisms underlying the acute effects of psychedelics, including changes in neuronal firing rates and excitability as well as alterations in functional connectivity between various brain nodes. In addition, animal studies using invasive recordings, have suggested synchronous high-frequency oscillations involving several brain regions as another key feature of the psychedelic brain state. To better understand how the imaging data might be related to high-resolution electrophysiological measurements, we have here analyzed the aperiodic part of the local field potential (LFP) in rodents treated with a classic psychedelic (LSD) or a dissociative anesthetic (ketamine). In addition, functional connectivity, as quantified by mutual information measures in the LFP time series, has been assessed with in and between different structures. Our data suggest that the altered brain states of LSD and ketamine are caused by different underlying mechanisms, where LFP power shifts indicate increased neuronal activity but reduced connectivity following ketamine, while LSD also leads to reduced connectivity but without an accompanying change in LFP broadband power.
Comparable studies
Other preclinical and animal studies on LSD, most cited first.
Citations in the library
Cited by 4
- 5-HT2AR and NMDAR psychedelics induce similar hyper-synchronous states in the rat cognitive-limbic cortex-basal ganglia system. Communications Biology July 26, 2023
- High-frequency oscillations in the mammalian brain after ketamine and other NMDA receptor antagonists. Journal of Psychopharmacology July 24, 2025
- Cellular mechanisms of serotonergic psychedelics - apical hypercontextualisation. Neuroscience & Biobehavioral Reviews July 1, 2026
- Psychosis: The Utility of Ketamine as a Pharmacological Model of Psychotic-like Symptoms in Rodents: A Review of Dosage Regimens Biology January 25, 2026
Cites 23
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and 18 more in the library