Les effets de l’ayahuasca sur le système nerveux central: étude comportementale
Laís M. S. de Lima, S. M. Ferreira, A. -a. L. Ávila, Fábio Ferreira Perazzo, José Maurício Schneedorf, Alexis Hinsberger, J.c.t. Carvalho
Phytothérapie December 1, 2007 DOI: 10.1007/s10298-007-0266-y (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Rats (implied by typical forced swimming and open-field tests) |
| Intervention | Ayahuasca |
| Dose | 2.5 mg/kg and 10 mg/kg |
| Topics | Ayahuasca |
| Citations | 28 |
| Key findings | Ayahuasca doses decreased immobility time in the forced swimming test in a dose-inversely proportional manner, and the 2.5 mg/kg dose showed antidepressant-like activity. |
Abstract
Un échantillon de la boisson ayahuasca contenant les alcaloïdes harmalol, harmol, harmane et N,N-diméthyltryptamine a été évalué dans les tests de nage forcée et d'open-field. Dans le test de nage forcée, les doses ont diminué le temps d'immobilité d'une manière inversement proportionnelle à la dose. Des doses de 2,5 mg/kg et de 10 mg/kg d'ayahuasca ont diminué aussi l'activité locomotrice et l'exploration verticale dans le test d'open-field. La dose de 2,5 mg/kg a amené à une diminution de l'activité locomotrice de 44,95% et de 62,12% pour l'exploration verticale. On peut avancer l'hypothèse d'une relation inversement proportionnelle entre dose et effet; la dose de 2,5 mg/kg a montré une activité antidépressive.
Comparable studies
Other preclinical and animal studies on ayahuasca, most cited first.
Citations in the library
Cited by 22
- Antidepressant effects of a single dose of ayahuasca in patients with recurrent depression: a preliminary report Brazilian Journal of Psychiatry March 1, 2015
- Ayahuasca: Pharmacology, neuroscience and therapeutic potential Brain Research Bulletin March 11, 2016
- The alkaloids of Banisteriopsis caapi, the plant source of the Amazonian hallucinogen Ayahuasca, stimulate adult neurogenesis in vitro Scientific Reports July 7, 2017
- Effects of N,N-Dimethyltryptamine on Rat Behaviors Relevant to Anxiety and Depression ACS Chemical Neuroscience April 17, 2018
- Antidepressive and anxiolytic effects of ayahuasca: a systematic literature review of animal and human studies Brazilian Journal of Psychiatry March 1, 2016
and 17 more in the library
Cites 5
- Monoamine oxidase inhibitors in South American hallucinogenic plants: Tryptamine and β-carboline constituents of Ayahuasca Journal of Ethnopharmacology April 1, 1984
- Subjective effects and tolerability of the South American psychoactive beverage Ayahuasca in healthy volunteers Psychopharmacology February 22, 2001
- Pharmacokinetics of Hoasca alkaloids in healthy humans. Journal of Ethnopharmacology June 1, 1999
- Differential interactions of dimethyltryptamine (DMT) with 5-HT1A and 5-HT2 receptors. Biochemical Pharmacology June 1, 1991
- Hallucinogenic drug interactions with neurotransmitter receptor binding sites in human cortex. Psychopharmacology 1989