JavaScript is disabled in your browser. You can still read and search, but features like search previews, menus, and forms may not work until it's enabled.

Differential interactions of dimethyltryptamine (DMT) with 5-HT1A and 5-HT2 receptors.

Biochem Pharmacol June 1, 1991 DOI: 10.1016/0006-2952(91)90178-8 (opens in new tab)

Relevant Not relevant

Study at a glance

AI-extracted from the abstract

Characteristics	Peer reviewed
Topics	5-MeO-DMT DMT

Abstract

Differential interactions of dimethyltryptamine (DMT) with 5-HT1A and 5-HT2 receptors.

Agonist Properties of N,N-Dimethyltryptamine at Serotonin 5-HT2A and 5-HT2C Receptors Pharmacology Biochemistry and Behavior November 1, 1998 142 citations
Serotonin 1A Receptors Modulate Serotonin 2A Receptor-Mediated Behavioral Effects of 5-Methoxy-N,N-dimethyltryptamine Analogs in Mice. ACS Chemical Neuroscience December 18, 2024 14 citations
Preclinical Comparison of DMT and 5-MeO-DMT Reveals Behavioral Dissociation, Distinct TrkB Activation and Differential Plasticity Profiles bioRxiv (Cold Spring Harbor Laboratory) August 12, 2026
Receptor interaction profiles of novel psychoactive tryptamines compared with classic hallucinogens. Eur Neuropsychopharmacol May 20, 2016 374 citations
The role of 5-HT2A, 5-HT2C and mGlu2 receptors in the behavioral effects of tryptamine hallucinogens N,N-dimethyltryptamine and N,N-diisopropyltryptamine in rats and mice Psychopharmacology July 2, 2014 67 citations