Increased platelet membrane [3H]‐LSD binding in patients on chronic neuroleptic treatment.
Michael Schächter, David P. Geaney, Dg Grahame‐smith, Philip J. Cowen, J.m. Elliott
British Journal of Clinical Pharmacology April 1, 1985 DOI: 10.1111/j.1365-2125.1985.tb02670.x (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational cohort Peer reviewed |
|---|---|
| Population | Schizophrenic patients treated with depot thioxanthenes and phenothiazines and controls |
| Intervention | depot thioxanthenes and phenothiazines |
| Topics | LSD Serotonin |
| Keywords | Platelet Pharmacology 5-HT Receptor Endocrinology Fluphenazine |
| Citations | 20 |
| Key findings | Schizophrenic patients on depot neuroleptics had an approximately 30% increase in platelet 5-HT receptor number and a roughly 30% decrease in receptor affinity compared to controls. |
Abstract
Using a [3H]‐lysergic acid diethylamide [(3H]‐LSD) binding technique, platelet 5‐hydroxytryptamine (5‐HT) receptor number and affinity were compared in schizophrenics treated with depot thioxanthenes and phenothiazines and controls. There was an approximately 30% increase in platelet receptor number (Bmax) in the patient group. There was a decrease in affinity (increase in Kd) of about 30% in the patient group. This was probably due to the persistence of the neuroleptic in the platelet membrane preparation. There was a weak positive correlation between receptor number and total neuroleptic dosage. The increased number of 5‐HT receptors is consistent with the previously reported enhancement of 5‐HT‐induced platelet aggregation in patients treated with long‐term phenothiazines and thioxanthenes. Our findings are compatible with 5‐HT up‐regulation in human platelets produced by depot neuroleptic therapy. It is not known whether parallel changes may be occurring in brain 5‐HT receptors.
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|---|---|---|---|
| Increased Global Functional Connectivity Correlates with LSD-Induced Ego Dissolution. Human participants | 2016 | Observational cohort | |
| Increased spontaneous MEG signal diversity for psychoactive doses of ketamine, LSD and psilocybin Humans | 2017 | Observational study | |
| Classic psychedelic use is associated with reduced psychological distress and suicidality in the United States adult population. USA adult respondents from the National Survey on Drug Use and Health (2008-2012) | 2015 | Observational cohort | n = 190,000 |
| Psychedelics not linked to mental health problems or suicidal behavior: A population study Randomly selected United States adults | 2015 | Observational cohort | n = 135,095 |
| Whole-Brain Multimodal Neuroimaging Model Using Serotonin Receptor Maps Explains Non-linear Functional Effects of LSD. Healthy human participants | 2018 | Observational study with computational modeling |