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Ecstasy (MDMA), amphetamine, and LSD: comparative mood profiles in recreational polydrug users

A. C. Parrott, Marta Stuart

Human Psychopharmacology: Clinical and Experimental September 1, 1997 DOI: 10.1002/(sici)1099-1077(199709/10)12:5<501::aid-hup913>3.0.co;2-v (opens in new tab)

Study at a glance

AI-extracted from the abstract
Characteristics Cross-sectional survey Peer reviewed
Sample size 21
Population Recreational polydrug users aged 17–34
Interventions MDMA LSD amphetamine
Topics LSD MDMA
Keywords Amphetamine Mood Feeling Hallucinogen Euphoriant Clinical psychology
Citations 24
Key findings MDMA produced intermediate effects on energy, confidence, and clearheadedness between amphetamine and LSD, but uniquely higher feelings of elation, agreeableness, and composure.

Abstract

Twenty-one recreational polydrug users (age range: 17–34 years), were recruited into the study using the 'snowball' technique (Solowij et al., 1992). All had used MDMA (3,4-methylenedioxymethamphetamine, or 'Ecstasy'), LSD (lysergic acid diethylamide), and amphetamine, on different occasions. They completed modified Profile of Mood States Questionnaires, to indicate their typical feeling states while on each drug. With three of the POMS factors, MDMA was intermediate between LSD and amphetamine, with feelings of energy, confidence and clearheadedness, highest under amphetamine, lowest on LSD, and intermediate after Ecstasy. However in other respects MDMA's mood profile was more unique, with significantly higher feelings of elation, agreeableness and composure, than the other two drugs. © 1997 John Wiley & Sons, Ltd.

Comparable studies

Other cross-sectional and survey studies on LSD, most cited first.

Study Year Design Participants
Survey of subjective "God encounter experiences": Comparisons among naturally occurring experiences and those occasioned by the classic psychedelics psilocybin, LSD, ayahuasca, or DMT Adults reporting a single most memorable God encounter experience, either nondrug or... 2019 Cross-sectional survey n = 4,285
Patterns of recreational drug use at dance events in Edinburgh, Scotland Drug users at dance events in Edinburgh, Scotland, UK, aged 16-47, 80% between 18 and... 2001 Cross-sectional survey n = 122
Development of the Psychological Insight Questionnaire among a sample of people who have consumed psilocybin or LSD Psilocybin and LSD users 2021 Cross-sectional survey study n = 1,661
Prevalence and associations of challenging, difficult or distressing experiences using classic psychedelics. US adult population 2023 Cross-sectional survey n = 2,822
Trends in LSD use among US adults: 2015-2018. US adults ages 18 and older 2020 Secondary analysis of cross-sectional survey data n = 168,562

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