Investigation into the temporal stability of aqueous standard solutions of psilocin and psilocybin using high performance liquid chromatography
Nicole Anastos, Neil W. Barnett, Frederick M. Pfeffer, Simon W. Lewis
Science & Justice April 1, 2006 DOI: 10.1016/s1355-0306(06)71579-9 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Duration | Fourteen days |
| Topics | Psilocybin |
| Keywords | Chromatography Ingredient Hallucinogen Detection limit |
| Citations | 27 |
| Key findings | Exclusion of light significantly prolonged the stability of aqueous psilocin and psilocybin solutions, with both remaining stable for seven days. |
Abstract
This paper reports an investigation into the temporal stability of aqueous solutions of psilocin and psilocybin reference drug standards over a period of fourteen days. This study was performed using high performance liquid chromatography utilising a (95:5% v/v) methanol: 10 mM ammonium formate, pH 3.5 mobile phase and absorption detection at 269 nm. It was found that the exclusion of light significantly prolonged the useful life of standards, with aqueous solutions of both psilocin and psilocybin being stable over a period of seven days.
Comparable studies
Other experimental studies on psilocybin, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Psilocybin induces schizophrenia-like psychosis in humans via a serotonin-2 agonist action Healthy human volunteers | 1998 | Experimental study | |
| Validation of the revised Mystical Experience Questionnaire in experimental sessions with psilocybin Participants in controlled laboratory experiments receiving a moderate to high oral... | 2015 | Validation study using pooled data from five laboratory experiments | n = 184 |
| Broadband Cortical Desynchronization Underlies the Human Psychedelic State Healthy human participants | 2013 | Experimental study | |
| Long-term follow-up of psilocybin-assisted psychotherapy for psychiatric and existential distress in patients with life-threatening cancer Participants with cancer-related psychiatric distress who completed a parent randomized... | 2020 | Long-term within-subjects follow-up analysis | n = 15 |
| Enzymatic Synthesis of Psilocybin | 2017 | Laboratory study |
Citations in the library
Cited by 11
- Psilocybin – Summary of knowledge and new perspectives European Neuropsychopharmacology December 17, 2013
- Stability of psilocybin and its four analogs in the biomass of the psychotropic mushroom Psilocybe cubensis Drug Testing and Analysis October 29, 2020
- Occurrence and use of hallucinogenic mushrooms containing psilocybin alkaloids TemaNord May 19, 2009
- Psilocybin containing mushrooms: a rapidly developing biotechnology industry in the psychiatry, biomedical and nutraceutical fields. 3 Biotech December 1, 2022
- Pharmacokinetics of Psilocybin, a Tryptamine Alkaloid in Magic Mushroom ( Psilocybe cubensis ): A Systematic Review Journal of Psychoactive Drugs September 10, 2024
and 6 more in the library
Cites 9
- Morphological and chemical analysis of magic mushrooms in Japan. Forensic Science International December 17, 2003
- Quantitative analysis of psilocybin and psilocin and psilocybe baecystis (singer and smith) by high-performance liquid chromatography and by thin-layer chromatography Journal of Chromatography A March 1, 1981
- Determination of psilocybin in hallucinogenic mushrooms by reversed-phase liquid chromatography with fluorescence detection Talanta January 7, 2005
- Determination of psilocin and psilocybin using flow injection analysis with acidic potassium permanganate and tris(2,2′-bipyridyl)ruthenium(II) chemiluminescence detection respectively Talanta February 17, 2005
- Analysis of Psilocybin and Psilocin in Mushroom Extracts by Reversed-Phase High Performance Liquid Chromatography Journal of Forensic Sciences October 1, 1980
and 4 more in the library