Genie in a blotter: A comparative study of LSD and LSD analogues' effects and user profile
Leigh Coney, Larissa J. Maier, Jason Ferris, Adam Winstock, Monica J Barratt
Human Psychopharmacology: Clinical and Experimental May 1, 2017 DOI: 10.1002/hup.2599 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Cross-sectional survey Peer reviewed |
|---|---|
| Sample size | 96,894 |
| Population | People who use drugs (Global Drug Survey 2016 respondents) |
| Topics | LSD |
| Keywords | Food science |
| Citations | 18 |
| Key findings | LSD analogues were reported as similar to LSD in time to peak and duration but weaker in strength, pleasurable high, and comedown. |
Abstract
Abstract Objective This study aimed to describe self‐reported patterns of use and effects of lysergic acid diethylamide (LSD) analogues (AL‐LAD, 1P‐LSD, and ETH‐LAD) and the characteristics of those who use them.
Methods: An anonymous self‐selected online survey of people who use drugs (Global Drug Survey 2016; N = 96,894), which measured perceived drug effects of LSD and its analogues.
Results: Most LSD analogue users (91%) had also tried LSD. The proportion of U.K. and U.S. respondents reporting LSD analogue use in the last 12 months was higher than for LSD only. LSD analogue users described the effects as psychedelic (93%), over half (55%) obtained it online, and almost all (99%) reported an oral route of administration. The modal duration (8 hr) and time to peak (2 hr) of LSD analogues were not significantly different from LSD. Ratings for pleasurable high, strength of effect, comedown, urge to use more drugs, value for money, and risk of harm following use were significantly lower for LSD analogues compared with LSD.
Conclusions: LSD analogues were reported as similar in time to peak and duration as LSD but weaker in strength, pleasurable high, and comedown. Future studies should seek to replicate these findings with chemical confirmation and dose measurement.
Comparable studies
Other cross-sectional and survey studies on LSD, most cited first.
Citations in the library
Cited by 12
- Designer drugs: mechanism of action and adverse effects Archives of Toxicology April 1, 2020
- Trends in LSD use among US adults: 2015-2018. Drug and Alcohol Dependence May 15, 2020
- Well-being, problematic alcohol consumption and acute subjective drug effects in past-year ayahuasca users: a large, international, self-selecting online survey Scientific Reports November 3, 2017
- Adverse experiences resulting in emergency medical treatment seeking following the use of lysergic acid diethylamide (LSD) Journal of Psychopharmacology June 7, 2022
- Effects of acute and repeated treatment with serotonin 5-HT2A receptor agonist hallucinogens on intracranial self-stimulation in rats. Experimental and Clinical Psychopharmacology January 10, 2019
and 7 more in the library
Cites 15
- Serotonin research: contributions to understanding psychoses TIPS - Trends in Pharmacological Sciences August 1, 2008
- The new drug phenomenon Drug Testing and Analysis July 1, 2014
- Animal Models of Serotonergic Psychedelics ACS Chemical Neuroscience September 24, 2012
- Dimethyltryptamine (DMT): Prevalence, user characteristics and abuse liability in a large global sample Journal of Psychopharmacology November 27, 2013
- Return of the lysergamides. Part I: Analytical and behavioural characterization of 1‐propionyl‐d‐lysergic acid diethylamide (1P‐LSD) Drug Testing and Analysis October 12, 2015
and 10 more in the library