Agonist-Directed Signaling of Serotonin 5-HT2C Receptors Differences Between Serotonin and Lysergic Acid Diethylamide (LSD)
Neuropsychopharmacology August 1, 1999 DOI: 10.1016/s0893-133x(99)00005-6 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Review Peer reviewed |
|---|---|
| Topics | LSD Serotonin |
| Keywords | 5-HT Receptor Pharmacology Endogenous agonist Endocrinology |
| Citations | 55 |
| Key findings | Signaling of LSD at 5-HT2C receptors differs from serotonin, and RNA editing of the 5-HT2C receptor alters LSD's stimulation of phosphatidylinositol signaling. |
Abstract
For more than 40 years the hallucinogen lysergic acid diethylamide (LSD) has been known to modify serotonin neurotransmission. With the advent of molecular and cellular techniques, we are beginning to understand the complexity of LSD's actions at the serotonin 5-HT2 family of receptors. Here, we discuss evidence that signaling of LSD at 5-HT2C receptors differs from the endogenous agonist serotonin. In addition, RNA editing of the 5-HT2C receptor dramatically alters the ability of LSD to stimulate phosphatidylinositol signaling. These findings provide a unique opportunity to understand the mechanism(s) of partial agonism.