Lysergic Acid Diethylamide (LSD) and Lisuride: Differentiation of Their Neuropharmacological Actions
Francis J. White, James B. Appel
Science April 30, 1982 DOI: 10.1126/science.7071600 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Animal discrimination study Peer reviewed |
|---|---|
| Population | Animals |
| Topics | LSD Serotonin |
| Keywords | Lisuride Quipazine Hallucinogen Apomorphine Dopamine agonist Pharmacology Serotonin agonist Partial agonist |
| Citations | 67 |
| Key points | The LSD cue is similar to the serotonin agonist quipazine, whereas the lisuride cue is similar to the dopamine agonist apomorphine, supporting serotonin's involvement in LSD's hallucinogenic effects. |
Abstract
The nonhallucinogenic ergot derivative lisuride exerts many pharmacological effects that are similar to those of its hallucinogenic congener, lysergic acid diethylamide (LSD). Animals trained to discriminate between the presence of one drug and the other can be used to differentiate the actions of these compounds on a neuronal level. The discriminative stimulus effect of LSD (the LSD cue) is similar to that of the serotonin agonist quipazine, whereas the lisuride cue is similar to that of the dopamine agonist apomorphine. These data support the hypothesis that serotonin is intricately involved in the hallucinogenic effects of LSD.
Citations in the library
Cited by 27
- Transcriptome Fingerprints Distinguish Hallucinogenic and Nonhallucinogenic 5-Hydroxytryptamine 2A Receptor Agonist Effects in Mouse Somatosensory Cortex Journal of Neuroscience October 1, 2003
- Correlation between the potency of hallucinogens in the mouse head-twitch response assay and their behavioral and subjective effects in other species. Neuropharmacology May 1, 2020
- The promises and perils of psychedelic pharmacology for psychiatry. Nature Reviews Drug Discovery June 1, 2022
- Dreams, Hallucinogenic Drug States, and Schizophrenia: A Psychological and Biological Comparison Schizophrenia Bulletin 1983
- Effect of Hallucinogens on Unconditioned Behavior Current Topics in Behavioral Neurosciences 2016
and 22 more in the library