Binding of [3H]lysergic Acid Diethylamide to Serotonin 5-HT2A Receptors and of [3H]paroxetine to Serotonin Uptake Sites in Platelets from Healthy Children, Adolescents and Adults
Jeanette Sigurdh, Olav Spigset, Per O. Allard, Tom Mjörndal, Bruno Hägglöf
Neuropsychobiology 1999 DOI: 10.1159/000026617 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational cohort Peer reviewed |
|---|---|
| Population | Healthy children (11-12 years), adolescents (16-17 years), and adults |
| Measures | [3H]LSD binding, [3H]paroxetine binding |
| Topics | LSD Serotonin |
| Key findings | Significant age effects were found for Bmax and Kd of both [3H]LSD and [3H]paroxetine binding. Bmax decreased with age, with 5-HT2A receptor decline occurring mainly between childhood and adolescence, and serotonin uptake site decline after adolescence. |
Abstract
Possible age effects on binding of [3H]lysergic acid diethylamide ([3H]LSD) to serotonin 5-HT2A receptors and of [3H]paroxetine to serotonin uptake sites were studied in platelets from healthy children (11–12 years of age), adolescents (16–17 years of age) and adults. Significant overall age effects were found both for the number of binding sites (Bmax) for [3H]LSD binding (p < 0.001), the affinity constant (Kd) for [3H]LSD binding (p < 0.001), Bmax for [3H]paroxetine binding (p < 0.001) and Kd for [3H] paroxetine binding (p = 0.006). In general, there was a decrease in Bmax with increasing age, which predominantly occurred between the ages 11–12 years and 16–17 years for the 5-HT2A receptor, and after 16–17 years of age for the serotonin uptake site. These developmental changes might have an impact on the effect of treatment with serotonergic drugs in children and adolescents. When the platelet serotonin variables investigated are employed in studies in children or adolescents, age matching or, alternatively, introduction of age control in the statistical analysis should be performed.
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| Psychedelics not linked to mental health problems or suicidal behavior: A population study Randomly selected United States adults | 2015 | Observational cohort | n = 135,095 |
| Whole-Brain Multimodal Neuroimaging Model Using Serotonin Receptor Maps Explains Non-linear Functional Effects of LSD. Healthy human participants | 2018 | Observational study with computational modeling |