SHORT-TERM EFFECTS OF LSD ON ANXIETY, ATTITUDES AND PERFORMANCE
William H. Mcglothlin, Sidney Cohen, Marcella S. Mcglothlin
The Journal of Nervous and Mental Disease September 1, 1964 DOI: 10.1097/00005053-196409000-00007 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Controlled trial Peer reviewed |
|---|---|
| Sample size | 29 |
| Population | Normal adults, mostly professional research personnel |
| Intervention | LSD |
| Dose | 25 mg |
| Duration | One-week follow-up |
| Topics | Anxiety LSD |
| Keywords | Term time Cognitive psychology |
| Citations | 27 |
| Key findings | LSD produced lower anxiety and reduced dogmatism and projection of aggression one week after administration, but did not improve performance on tests of fluency, flexibility, or originality beyond practice effects. |
Abstract
This study describes the short-term effects of administering LSD to normals as measured by pre and one-week-post-LSD tests of anxiety, attitudes, and performance. The hypothesis tested was that LSD would produce a rapid lowering of defenses resulting in (1) lower anxiety, (2) attitudinal changes, particularly in the form of decreased dogmatism and projection of aggression, and (3) increases in certain performance tests of fluency, flexibility, and originality. The samples consisted of 15 experimental and 14 com parison subjects, most of whom were professional research personnel. The hypothesis was generally confirmed for the anxiety and attitude tests, but there were no gains in the performance tests beynd that attributable to practice effect as measured in the comparison group. An attempt was made to determine if certain LSD-induced changes in the word-association test results, as found in a previous study, were retained in the post-LSD period. The results were incon clusive, apparently because of the lack of similarity between the samples of subjects. A larger study is planned using a six-month follow-up period. (Author)