Mutagenicity testing of 3 hallucinogens: LSD, psilocybin and‡ 9-THC using the micronucleus test
Cellular and Molecular Life Sciences March 1, 1978 DOI: 10.1007/bf01923013 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Mice |
| Interventions | LSD psilocybin delta-9-THC |
| Dose | 3 logarithmically increasing doses |
| Topics | Psilocybin Cannabis LSD |
| Keywords | Hallucinogen Micronucleus test Pharmacology |
| Citations | 43 |
| Key findings | LSD, psilocybin, and delta-9-THC did not cause a significant increase in micronuclei in mice, while azathioprine did. |
Abstract
Using the micronucleus test as a screening method for mutagenic activity, no significant increase in the number of micronuclei was found when LSD, psilocybin or delta 9-THC were administered in 3 logarithmically increasing doses to mice, Azathioiprine (Imuran), given as a positive control, caused a statistically significantt increase in the micronucleated cells.
Comparable studies
Other preclinical and animal studies on LSD, most cited first.
Citations in the library
Cited by 13
- The pharmacology of psilocybin Addiction Biology October 1, 2002
- The abuse potential of medical psilocybin according to the 8 factors of the Controlled Substances Act Neuropharmacology June 5, 2018
- Psilocybin – Summary of knowledge and new perspectives European Neuropsychopharmacology December 17, 2013
- Occurrence and use of hallucinogenic mushrooms containing psilocybin alkaloids TemaNord May 19, 2009
- Antidepressant- and anxiolytic-like activities and acute toxicity evaluation of the Psilocybe cubensis mushroom in experimental models in mice. Journal of Ethnopharmacology February 10, 2024
and 8 more in the library