LSD Revisited
Archives of General Psychiatry 1971 DOI: 10.1001/archpsyc.1971.01750070037005 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational cohort Peer reviewed |
|---|---|
| Sample size | 247 |
| Population | Persons who received LSD in experimental or psychotherapeutic settings |
| Intervention | LSD |
| Topics | LSD |
| Keywords | Personality Limiting Clinical psychology Drug |
| Citations | 116 |
| Key findings | LSD use produced little measurable lasting personality, belief, value, attitude, or behavior change in the sample as a whole, and compulsive use rarely developed. |
Abstract
A follow-up survey of 247 persons who received d-lysergic acid diethylamide (LSD) in either an experimental (nonmedical) or Psychotherapeutic setting was made to determine the lasting effects, if any, related to use of the drug. Information was collected from each by a structured interview and self-administered questionnaire. Some subsequent nonmedical use of LSD was reported by 23%, who attributed more personality changes to the drug's use. There is, however, little evidence that measurable, lasting personality, belief, value, attitude, or behavior changes were produced in the sample as a whole. Compulsive patterns of LSD use rarely developed; the nature of the drug effect apparently is such that it becomes less attractive with continued use and, in the long-term, is almost always self-limiting.
Comparable studies
Other observational and cohort studies on LSD, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Increased Global Functional Connectivity Correlates with LSD-Induced Ego Dissolution. Human participants | 2016 | Observational cohort | |
| Increased spontaneous MEG signal diversity for psychoactive doses of ketamine, LSD and psilocybin Humans | 2017 | Observational study | |
| Classic psychedelic use is associated with reduced psychological distress and suicidality in the United States adult population. USA adult respondents from the National Survey on Drug Use and Health (2008-2012) | 2015 | Observational cohort | n = 190,000 |
| Psychedelics not linked to mental health problems or suicidal behavior: A population study Randomly selected United States adults | 2015 | Observational cohort | n = 135,095 |
| Whole-Brain Multimodal Neuroimaging Model Using Serotonin Receptor Maps Explains Non-linear Functional Effects of LSD. Healthy human participants | 2018 | Observational study with computational modeling |
Citations in the library
Cited by 56
- The entropic brain: a theory of conscious states informed by neuroimaging research with psychedelic drugs Frontiers in Human Neuroscience 2014
- Human hallucinogen research: guidelines for safety. Journal of Psychopharmacology July 1, 2008
- Mystical experiences occasioned by the hallucinogen psilocybin lead to increases in the personality domain of openness Journal of Psychopharmacology September 28, 2011
- Acute, subacute and long-term subjective effects of psilocybin in healthy humans: a pooled analysis of experimental studies Journal of Psychopharmacology September 20, 2010
- Classic psychedelics: An integrative review of epidemiology, therapeutics, mystical experience, and brain network function. Pharmacology & Therapeutics May 1, 2019
and 51 more in the library
Cites 9
- Altered States of Consciousness Archives of General Psychiatry September 1, 1966
- On the Use and Abuse of LSD Archives of General Psychiatry March 1, 1968
- Flashbacks: Recurrent Intrusive Images After the Use of LSD American Journal of Psychiatry October 1, 1969
- Long Lasting Effects of LSD on Normals Archives of General Psychiatry November 1, 1967
- A Clinical Study of LSD Treatment in Alcoholism American Journal of Psychiatry July 1, 1969
and 4 more in the library