Acute Lysergic Acid Diethylamide Does Not Influence Reward-Driven Decision Making of C57BL/6 Mice in the Iowa Gambling Task

Lauri Elsilä; Nuppu Korhonen; Petri Hyytiä; Esa R. Korpi

doi:10.3389/fphar.2020.602770

Acute Lysergic Acid Diethylamide Does Not Influence Reward-Driven Decision Making of C57BL/6 Mice in the Iowa Gambling Task

Lauri Elsilä, Nuppu Korhonen, Petri Hyytiä, Esa R. Korpi

Frontiers in Pharmacology December 3, 2020 DOI: 10.3389/fphar.2020.602770 (opens in new tab)

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Study at a glance

AI-extracted from the abstract

Characteristics	Experimental study Peer reviewed
Sample size	15
Population	Mice
Interventions	LSD 25CN-NBOH d-amphetamine saline
Dose	0.025, 0.1, 0.2, 0.4 mg/kg (LSD), 1.5 mg/kg (25CN-NBOH), 2.0 mg/kg (d-amphetamine)
Topics	LSD Serotonin
Keywords	Amphetamine Iowa gambling task Hallucinogen Pharmacology Agonist
Citations	13
Key findings	LSD at doses up to 0.2 mg/kg did not affect reward-driven decision making in mice, while the highest dose (0.4 mg/kg) reduced premature responding and increased omission rates without altering option selection.

Abstract

While interest in psychedelic drugs in the fields of psychiatry and neuroscience has re-emerged in recent last decades, the general understanding of the effects of these drugs remains deficient. In particular, there are gaps in knowledge on executive functions and goal-directed behaviors both in humans and in commonly used animal models. The effects of acute doses of psychedelic lysergic acid diethylamide (LSD) on reward-driven decision making were explored using the mouse version of the Iowa Gambling Task. A total of 15 mice were trained to perform in a touch-screen adaptation of the rodent version of the Iowa Gambling Task, after which single acute doses of LSD (0.025, 0.1, 0.2, 0.4 mg/kg), serotonin 2A receptor-selective agonist 25CN-NBOH (1.5 mg/kg), d -amphetamine (2.0 mg/kg), and saline were administered before the trial. 25CN-NBOH and the three lowest doses of LSD showed no statistically significant changes in option selection or in general functioning during the gambling task trials. The highest dose of LSD (0.4 mg/kg) significantly decreased premature responding and increased the omission rate, but had no effect on option selection in comparison with the saline control. Amphetamine significantly decreased the correct responses and premature responding while increasing the omission rate. In conclusion, mice can perform previously learned, reward-driven decision-making tasks while under the acute influence of LSD at a commonly used dose range.

Comparable studies

Other preclinical and animal studies on LSD, most cited first.

Study	Year	Design
Transcriptome Fingerprints Distinguish Hallucinogenic and Nonhallucinogenic 5-Hydroxytryptamine 2A Receptor Agonist Effects in Mouse Somatosensory Cortex Human embryonic kidney 293 cells stably expressing 5-HT2ARs; wild-type and 5-HT2AR...	2003	Experimental study
Evidence for a central 5‐hydroxytryptamine receptor stimulation by lysergic acid diethylamide Rats	1968	Experimental study
Psychedelics, but Not Ketamine, Produce Persistent Antidepressant-like Effects in a Rodent Experimental System for the Study of Depression Rats	2020	Preclinical study
Lysergic acid diethylamide (LSD) promotes social behavior through mTORC1 in the excitatory neurotransmission Male mice	2021	Multidisciplinary experimental study with in vivo electrophysiology, optogenetics, behavioral paradigms, molecular biology, and conditional knockout mice
A non-hallucinogenic LSD analog with therapeutic potential for mood disorders. Mice and cultured rat cortical neurons	2023	Preclinical study

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