Pholiotina cyanopus, a rare fungus producingpsychoactive tryptamines
Marek Halama, Anna Poliwoda, Іzabela Jasicka-Misiak, Piotr Wieczorek, Ryszard Rutkowski
Open Life Sciences November 19, 2014 DOI: 10.1515/biol-2015-0005 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational study with chemical analysis Peer reviewed |
|---|---|
| Population | Pholiotina cyanopus basidiomata collected from wood chips and woody remnants in Poland |
| Topics | Psilocybin |
| Keywords | Basidiocarp Tryptamines Dry weight Botany |
| Key findings | Pholiotina cyanopus contains high levels of psilocybin (0.90±0.08% dry weight) and, for the first time, norbaeocystin and aeruginascin were detected in the species. |
Abstract
Abstract Pholiotina cyanopus was collected from wood chips and other woody remnants of undetermined tree species. Its basidiomata were found in June within the area of closed sawmill in the central part of Żywiec city (SW Poland). Description and illustration of Ph. cyanopus based on Polish specimens are provided and its ecology, general distribution and comparison with similar taxa – Pholiotina smithii, Pholiotina sulcatipes , and others are discussed as well. The identity of the active compounds of Ph. cyanopus was additionally determined. Liquid chromatography–mass spectrometry (LC-MS) data sets were obtained to support the occurrence of psilocybin and its analogues – psilocin, baeocystin, norbaeocystin, and aeruginascin in air-dried basidiomata of the species. The content of psilocybin was found to be high (0.90±0.08% of dry weight), besides, analysed samples contained lower concentrations of psilocin (0.17±0.01%), and baeocystin (0.16±0.01%). Additionally, the chemical analysis revealed small amounts of norbaeocystin (0.053±0.004%) and aeruginascin (0.011±0.0007%) for the first time in the species.
Comparable studies
Other observational and cohort studies on psilocybin, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Psilocybin for treatment-resistant depression: fMRI-measured brain mechanisms. Patients with treatment-resistant depression | 2017 | Observational cohort | n = 19 |
| Psychedelic effects of psilocybin correlate with serotonin 2A receptor occupancy and plasma psilocin levels Healthy volunteers | 2019 | Observational cohort | n = 8 |
| Increased spontaneous MEG signal diversity for psychoactive doses of ketamine, LSD and psilocybin Humans | 2017 | Observational study | |
| Classic psychedelic use is associated with reduced psychological distress and suicidality in the United States adult population. USA adult respondents from the National Survey on Drug Use and Health (2008-2012) | 2015 | Observational cohort | n = 190,000 |
| Prediction of Psilocybin Response in Healthy Volunteers Healthy volunteers | 2012 | Observational cohort | n = 409 |
Citations in the library
Cites 8
- Hallucinogenic mushrooms on the German market - simple instructions for examination and identification. Forensic Science International September 11, 2000
- Psilocybin and psilocin levels in twenty species from seven genera of wild mushrooms in the Pacific Northwest, U.S.A. Journal of Ethnopharmacology May 1, 1982
- Aeruginascin, a Trimethylammonium Analogue of Psilocybin from the Hallucinogenic MushroomInocybe aeruginascens Planta Medica April 1, 2006
- Occurrence and use of hallucinogenic mushrooms containing psilocybin alkaloids TemaNord May 19, 2009
- Analysis of Aeruginascin in Fruit Bodies of the Mushroom Inocybe aeruginascens International Journal of Crude Drug Research 1989
and 3 more in the library