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Psychedelics are Bringing a new wind to the Pharmacopoeia

Michel Bourin

Neuroscience and Neurological Surgery February 27, 2025 DOI: 10.31579/2578-8868/360 (opens in new tab) via OpenAlex

Summary

AI-generated from the abstract

Hundreds of clinical trials worldwide are testing hallucinogenic substances—psilocybin, LSD, DMT, mescaline, MDMA, and ketamine—for their ability to restore mental health. Psilocybin is the active ingredient in hallucinogenic mushrooms, LSD derives from ergot compounds, DMT is part of ayahuasca, mescaline comes from peyote, and MDMA is an amphetamine known as ecstasy.

Study at a glance

Characteristics Review Peer reviewed
Keywords Pharmacopoeia Geography
Key finding Several hundred clinical trials are testing hallucinogenic substances for their ability to restore mental health.

Abstract

Hallucinogenic substances such as psilocybin, LSD or ecstasy are now the subject of several hundred clinical trials around the world to test their ability to restore our mental health. Psilocybin (active ingredient in hallucinogenic mushrooms), LSD (derived from compounds from ergot), dimethyltryptamine (or DMT, part of the composition of ayahuasca), mescaline (derived from peyote), but also MDMA ( amphetamine better known under the name ecstasy) or even ketamine.

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