Is psilocybin only effective as part of psychotherapy?
Zenodo (CERN European Organization for Nuclear Research) January 22, 2026 preprint DOI: 10.5281/zenodo.18339347 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Review |
|---|---|
| Intervention | Psilocybin |
| Topics | Psilocybin |
| Keywords | Pharmacology Intensive care medicine Medline Clinical trial Current fluid |
| Key findings | Psilocybin is effective when combined with psychotherapy and may also have beneficial effects with less intensive psychological support. |
Abstract
Current evidence mainly shows psilocybin's effectiveness when combined with psychotherapy, but there is also evidence suggesting it can have beneficial effects with less intensive psychological support. Further research is needed to clarify its efficacy as a standalone treatment.
Comparable studies
Other narrative reviews on psilocybin, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Classic psychedelics: An integrative review of epidemiology, therapeutics, mystical experience, and brain network function. General population | 2019 | Integrative review | |
| The pharmacology of psilocybin | 2002 | Review | |
| Serotonin research: contributions to understanding psychoses | 2008 | Review | |
| Psychedelics, Meditation, and Self-Consciousness | 2018 | Review | |
| The abuse potential of medical psilocybin according to the 8 factors of the Controlled Substances Act | 2018 | Review |