Scoping Review: The Role of Psychedelics in the Management of Chronic Pain
Christopher L. Robinson, Alexandra Fonseca, Efemena Diejomaoh, Ryan S. D’souza, Michael E Schatman, Vwaire Orhurhu, Trent Emerick
Journal of Pain Research March 1, 2024 DOI: 10.2147/jpr.s439348 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Review Randomized Placebo-controlled Double-blind Peer reviewed |
|---|---|
| Topics | Psilocybin |
| Keywords | Chronic pain Medline Hallucinogen |
| Citations | 32 |
| Key findings | Psychedelics may have potential in alleviating pain symptoms secondary to a multitude of chronic pain conditions, but further randomized, double-blind, placebo-controlled trials are needed. |
Abstract
Psychedelics may have potential in alleviating pain symptoms secondary to a multitude of chronic pain conditions. However, further randomized, double-blind, placebo-controlled trials are needed to further explore and evaluate the role of psychedelics in chronic, non-cancer pain.
Comparable studies
Other narrative reviews on psilocybin, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Classic psychedelics: An integrative review of epidemiology, therapeutics, mystical experience, and brain network function. General population | 2019 | Integrative review | |
| The pharmacology of psilocybin | 2002 | Review | |
| Serotonin research: contributions to understanding psychoses | 2008 | Review | |
| Psychedelics, Meditation, and Self-Consciousness | 2018 | Review | |
| The abuse potential of medical psilocybin according to the 8 factors of the Controlled Substances Act | 2018 | Review |
Citations in the library
Cited by 26
- Fibromyalgia: one year in review 2025. Clinical and experimental rheumatology June 1, 2025
- Psilocybin as a novel treatment for chronic pain British Journal of Pharmacology November 29, 2024
- Classic Psychedelics in Pain Modulation: Mechanisms, Clinical Evidence, and Future Perspectives ACS Chemical Neuroscience June 6, 2025
- Pain and Perception: Exploring Psychedelics as Novel Therapeutic Agents in Chronic Pain Management. Current Pain and Headache Reports January 7, 2025
- Refractory CRPS pain treated with psilocybin: A case report Clinical Case Reports September 1, 2024
and 21 more in the library
Cites 23
- Adverse effects of psychedelics: From anecdotes and misinformation to systematic science. Journal of Psychopharmacology February 2, 2022
- Psychedelics as anti-inflammatory agents International Review of Psychiatry July 4, 2018
- Response of cluster headache to psilocybin and LSD Neurology June 26, 2006
- Hallucinogens in Mental Health: Preclinical and Clinical Studies on LSD, Psilocybin, MDMA, and Ketamine Journal of Neuroscience November 30, 2020
- The Therapeutic Potential of Psilocybin Molecules May 15, 2021
and 18 more in the library