Hallucinogen Persistent Perception Disorder Induced by New Psychoactive Substituted Phenethylamines; A Review with Illustrative Case
Cornel N. Stanciu, Thomas M. Penders
Current Psychiatry Reviews August 10, 2016 DOI: 10.2174/1573400512999160803102947 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Case study Case report Peer reviewed |
|---|---|
| Sample size | 1 |
| Population | A single patient with HPPD due to high dose 2C-E |
| Intervention | lamotrigine |
| Topics | LSD Mescaline Psilocybin |
| Keywords | Hallucinogen Phenethylamines Designer drug Psychoactive substance Tryptamines |
| Citations | 3 |
| Key findings | The first documented case of HPPD due to high dose 2C-E showed symptom blunting with lamotrigine. |
Abstract
Hallucinogen Persistent Perception Disorder (HPPD) is considered an “uncommon” disorder described in association with use of hallucinogens such as LSD, mescaline and psilocybin. Despite multiple mentions of persistence of visual disturbances reported by users on online forums, clinicians may not be aware of this complication. There have been few descriptions of HPPD in association with use of new psychoactive substances (such as 2C-E). Increasing use of these designer stimulants places greater numbers at risk for psychiatric morbidities including HPPD. Here we report the first documented case of HPPD due to high dose 2C-E and blunting of symptoms with addition of lamotrigine. Keywords: Stimulants, hallucinogen, psychoactive, phenylethylamines.
Comparable studies
Other case reports and case series on mescaline, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Parkinsonism after Taking Ecstasy 29-year-old man | 1999 | Case study | n = 1 |
| Methylenedioxyamphetamine. Clinical description of overdose, death, and review of pharmacology A patient with methylenedioxyamphetamine intoxication | 1981 | Case study | n = 1 |
| A New Hallucinogen: 3,4,5-Trimethoxyphenyl-β-Aminopropane | 1955 | Case study | |
| Peyote and mescaline exposures: a 12-year review of a statewide poison center database Patients who used peyote or mescaline and required treatment | 2010 | Case series | |
| A Mescaline Associated Fatality A single deceased individual under the influence of mescaline | 1985 | Case study | n = 1 |
Citations in the library
Cited by 2
- Apophenia, absorption and anxiety: Evidence for individual differences in positive and negative experiences of Hallucinogen Persisting Perceptual Disorder Journal of Psychedelic Studies August 8, 2022
- Pharmacological Treatment of Hallucinogen Persisting Perception Disorder (HPPD): A Systematic Review. Harvard Review of Psychiatry September 9, 2025