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XXXVIII. Comparison with Action of Methysergide and Psilocybin on Test Subjects

Harold A. Abramson, Anabela P. Rolo

Journal of Asthma Research 1965 DOI: 10.3109/02770906509106904 (opens in new tab)

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Study at a glance

AI-extracted from the abstract
Characteristics Experimental comparison Peer reviewed
Population Non-psychotic test subjects
Interventions LSD-25 psilocybin psilocin methysergide
Topics LSD Mescaline Psilocybin
Keywords Methysergide Psychotomimetic Hallucinogen Pharmacology
Citations 21
Key findings Methysergide produces side effects and tolerance, and its effects were compared with LSD-25, psilocybin, and psilocin in over 150 experiments.

Abstract

This paper is a continuation of our experiments with LSD-25 and similar compounds that have been carried out for the last thirteen years.1 It employs the same technique described previously2 to compare these drugs on non-psychotic test subjects under suitable conditions. The conditions of the experiment are most important because under certain circumstances the experimental milieu produces so much anxiety that the environment may be said to affect the results as much as the drug itself. Of particular importance is the growing use of methysergide (Sansert) in the treatment of migraine. The frequent occurrence of side affects due to Sansert and the apparent development of tolerance to this derivative of d-lysergic acid has led us to explore the effects of methysergide (Sansert) in the same test subjects used in the study of psychotomimetic drugs for the past ten years. The present series of experiments comparing LSD-25, psilocybin, psilocin and methysergide were begun in 1958. This communication will report on more that 150 experiments with these drugs.

Comparable studies

Other experimental studies on psilocybin, most cited first.

Study Year Design Participants
Psilocybin induces schizophrenia-like psychosis in humans via a serotonin-2 agonist action Healthy human volunteers 1998 Experimental study
Validation of the revised Mystical Experience Questionnaire in experimental sessions with psilocybin Participants in controlled laboratory experiments receiving a moderate to high oral... 2015 Validation study using pooled data from five laboratory experiments n = 184
Broadband Cortical Desynchronization Underlies the Human Psychedelic State Healthy human participants 2013 Experimental study
Long-term follow-up of psilocybin-assisted psychotherapy for psychiatric and existential distress in patients with life-threatening cancer Participants with cancer-related psychiatric distress who completed a parent randomized... 2020 Long-term within-subjects follow-up analysis n = 15
Enzymatic Synthesis of Psilocybin 2017 Laboratory study

Citations in the library

Cited by 11

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Cites 3

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