Lifetime Psychedelic Use and Opioid Use Disorder Severity: Substance-Use Pattern Specific and Mental Health–Dependent Associations in a National Survey
Sebastian Ehmann, Nathan M. Hager, Paul S. Regier, Grant Jones, John JB Allen
PsyArXiv November 2, 2025 preprint DOI: 10.31234/osf.io/jd2rk_v1 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Cross-sectional survey |
|---|---|
| Population | US adults from a national survey |
| Topics | Addiction |
| Keywords | Psychedelics Psychedelic use Hallucinogens Entheogens Psychoactive substances Oud Opioid addiction Opioid dependence Addiction treatment Therapeutic potential Substance abuse treatment Harm reduction Drug therapy |
| Key findings | Lifetime psychedelic use is associated with lower opioid use disorder severity only in certain substance-use patterns and is mediated by mental health. |
Abstract
Lifetime Psychedelic Use and Opioid Use Disorder Severity: Substance-Use Pattern Specific and Mental Health–Dependent Associations in a National Survey