Salvinorin A and Salvia divinorum: Toxicology, Pharmacological Profile, and Therapeutic Potential.
Int J Mol Sci June 11, 2025 DOI: 10.3390/ijms26125588 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Review Peer reviewed |
|---|---|
| Topics | Salvia divinorum |
| Keywords | Natural compound Unique compound Psychoactive substance Therapeutic potential Medical applications Medicinal use Drug development Pharmacological promise Kappa-opioid receptors Brain receptors Receptor interaction Mechanism of action Neuropharmacology Pain relief Analgesia Pain management Addiction treatment Mood disorder treatment Psychiatric treatment |
| Citations | 4 |
| Key findings | Salvia divinorum presents both potential therapeutic applications and health risks, with its complex pharmacological profile warranting further research. |
Abstract
Salvia divinorum is a psychoactive plant presenting a complex pharmacological profile, attracting significant scientific interest due to its potential therapeutic applications and associated health risks. This review provides a comprehensive analysis of the toxic and therapeutic effects of S. divinorum, evaluating its potential medical applications while highlighting the risks associated with its consumption. Additionally, the review examines the plant’s recreational use, global consumption trends, and legal status. By synthesising current research, this article aims to clarify the implications of S. divinorum use and inform future studies on its pharmacological potential and regulatory considerations.