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Psychedelic-assisted psychotherapy to treat psychiatric and existential distress in life-threatening medical illnesses and palliative care.

S Ross, M Agrawal, Roland R. Griffiths, C Grob, Ann Berger, Jack E Henningfield

Neuropharmacology September 15, 2022 DOI: 10.1016/j.neuropharm.2022.109174 (opens in new tab)

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Study at a glance

AI-extracted from the abstract
Characteristics Commentary Peer reviewed
Population Patients with life-threatening medical illnesses and palliative care
Intervention psychedelic-assisted psychotherapy
Topics Anxiety Depression End-of-life distress Psychedelic-assisted therapy
Keywords Demoralization syndrome Palliative care Psychedelics Mental health
Citations 69
Key points Argues that psychedelic-assisted psychotherapy warrants further research as a treatment for psychiatric and existential distress in life-threatening medical conditions and palliative care.

Abstract

Psychiatric and existential distress commonly occur in advanced cancer and other serious, life-threatening or end-of-life medical illnesses and are associated with poor medical and psychiatric outcomes. Currently available treatment modalities in this patient population, including medication and psychotherapy, are limited in effectiveness, especially regarding existential distress. The lack of effective psycho-spiritual interventions is a critical shortcoming in palliative care and represents a high unmet need in medicine. In this commentary, we review the rationale of researching and developing psychedelic-assisted psychotherapy as a novel pharmacologic-psychotherapeutic intervention to treat psychiatric and existential distress in life-threatening medical conditions and palliative care. This paper reviews efficacy data from first and second waves of psychedelic research, and future directions for research and implementation science. More rigorous research, especially funded by governments, is needed to assess effectiveness and mechanisms of action of psychedelic therapies to treat psychiatric and existential distress in life-threatening medical illnesses and palliative care. If psychedelic-assisted treatments were made available as approved and prescribable medications in people with serious medical illnesses, it could be a significant development that opens up a pathway for clinical dissemination and public health impact internationally.

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  • State of the evidence: End-of-life distress Supports

    Argues that psychedelic-assisted psychotherapy warrants further research as a treatment for psychiatric and existential distress in life-threatening illness and palliative care, noting current treatments are limited especially for existential distress.

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Anxiety Depression End-of-life distress Psychedelic-assisted therapy