Common neural signatures of psychedelics: Frequency-specific energy changes and repertoire expansion revealed using connectome-harmonic decomposition.
Selen Atasoy, Jakub Vohryzek, Gustavo Deco, Robin Carhart-Harris, Morten L. Kringelbach
Progress in Brain Research October 25, 2018 DOI: 10.1016/bs.pbr.2018.08.009 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Theoretical or philosophical paper Peer reviewed |
|---|---|
| Interventions | Psilocybin LSD |
| Keywords | Psychedelics: psychedelic compounds Substances Various psychedelics Brain wave rhythms Brain imaging analysis Brain function Brain states Neuroplasticity: enhanced flexibility Brain's 'repertoire' Adaptable Diverse neural landscape Brain flexibility Mental health |
| Citations | 67 |
| Key points | The authors propose that connectome-harmonic decomposition describes brain activity in any mental state, and report that psilocybin and LSD produce remarkably similar increases in total energy and power, frequency-specific energy changes, repertoire expansion, and enhanced signatures of criticality, suggesting brain dynamics tune toward criticality in both psychedelic states. |
Abstract
The search for the universal laws of human brain function is still on-going but progress is being made. Here we describe the novel concepts of connectome harmonics and connectome-harmonic decomposition, which can be used to characterize the brain activity associated with any mental state. We use this new frequency-specific language to describe the brain activity elicited by psilocybin and LSD and find remarkably similar effects in terms of increases in total energy and power, as well as frequency-specific energy changes and repertoire expansion. In addition, we find enhanced signatures of criticality suggesting that the brain dynamics tune toward criticality in both psychedelic elicited states. Overall, our findings provide new evidence for the remarkable ability of psychedelics to change the spatiotemporal dynamics of the human brain.
Citations in the library
Cited by 44
- Dynamical exploration of the repertoire of brain networks at rest is modulated by psilocybin. Neuroimage May 25, 2019
- LSD alters dynamic integration and segregation in the human brain. Neuroimage February 15, 2021
- Receptor-informed network control theory links LSD and psilocybin to a flattening of the brain's control energy landscape. Nature Communications October 3, 2022
- Updating the dynamic framework of thought: Creativity and psychedelics. Neuroimage March 8, 2020
- Distributed harmonic patterns of structure-function dependence orchestrate human consciousness. Communications Biology January 28, 2023
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Cites 33
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- Neural correlates of the LSD experience revealed by multimodal neuroimaging. Proceedings of the National Academy of Sciences April 11, 2016
and 28 more in the library