Hallucinations Under Psychedelics and in the Schizophrenia Spectrum: An Interdisciplinary and Multiscale Comparison
Pantelis Leptourgos, Martin Fortier-Davy, Robin Carhart-Harris, Philip R. Corlett, David Dupuis, Adam L. Halberstadt, Michael Kometer, Eva Kozáková, Frank Larøi, Tehseen Noorani, Katrin H. Preller, Flavie Waters, Yuliya Zaytseva, Renaud Jardri
Schizophrenia Bulletin August 5, 2020 DOI: 10.1093/schbul/sbaa117 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Review Peer reviewed |
|---|---|
| Topics | Psilocybin |
| Keywords | Psychosis Schizophrenia spectrum Multidisciplinary approach Schizophrenia object-oriented programming The renaissance Phenomenology philosophy Broad spectrum Schizophrenia research Similarity geometry Clinical psychology Psychotherapist Hallucinogen Social science Epistemology Artificial intelligence |
| Citations | 88 |
| Key findings | Hallucinations under psychedelics and in schizophrenia-spectrum disorders show both similarities and differences across pharmacological, neural, phenomenological, and anthropological levels of analysis. |
Abstract
Abstract The recent renaissance of psychedelic science has reignited interest in the similarity of drug-induced experiences to those more commonly observed in psychiatric contexts such as the schizophrenia-spectrum. This report from a multidisciplinary working group of the International Consortium on Hallucinations Research (ICHR) addresses this issue, putting special emphasis on hallucinatory experiences. We review evidence collected at different scales of understanding, from pharmacology to brain-imaging, phenomenology and anthropology, highlighting similarities and differences between hallucinations under psychedelics and in the schizophrenia-spectrum disorders. Finally, we attempt to integrate these findings using computational approaches and conclude with recommendations for future research.
Comparable studies
Other narrative reviews on psilocybin, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Classic psychedelics: An integrative review of epidemiology, therapeutics, mystical experience, and brain network function. General population | 2019 | Integrative review | |
| The pharmacology of psilocybin | 2002 | Review | |
| Serotonin research: contributions to understanding psychoses | 2008 | Review | |
| Psychedelics, Meditation, and Self-Consciousness | 2018 | Review | |
| The abuse potential of medical psilocybin according to the 8 factors of the Controlled Substances Act | 2018 | Review |
Citations in the library
Cited by 62
- Serotonergic psychedelic drugs LSD and psilocybin reduce the hierarchical differentiation of unimodal and transmodal cortex. Neuroimage April 25, 2022
- Neural Mechanisms and Psychology of Psychedelic Ego Dissolution Pharmacological Reviews September 9, 2022
- Psychedelics, Sociality, and Human Evolution Frontiers in Psychology September 29, 2021
- Psychedelic perceptions: mental health service user attitudes to psilocybin therapy Irish Journal of Medical Science June 15, 2021
- Psychedelic Therapy's Transdiagnostic Effects: A Research Domain Criteria (RDoC) Perspective Frontiers in Psychiatry December 17, 2021
and 57 more in the library
Cites 51
- The Brain's Default Mode Network Annual Review of Neuroscience May 4, 2015
- Neural correlates of the psychedelic state as determined by fMRI studies with psilocybin Proceedings of the National Academy of Sciences January 23, 2012
- Human hallucinogen research: guidelines for safety. Journal of Psychopharmacology July 1, 2008
- REBUS and the Anarchic Brain: Toward a Unified Model of the Brain Action of Psychedelics Pharmacological Reviews June 20, 2019
- Psilocybin induces schizophrenia-like psychosis in humans via a serotonin-2 agonist action Neuroreport December 1, 1998
and 46 more in the library