Cross-species mapping of psychedelic gene expression reveals links to the 5HT2A receptor, cortical layers, and human accelerated regions
Patrick A. McConnell, Jackson Raffety, Andrew Li, Eric Steinberg, Syed Rahim, Christian Valtierra, Adam Gazzaley, Robin Carhart-Harris, Lorenzo Pasquini
Research Square October 3, 2025 preprint DOI: 10.21203/rs.3.rs-7625999/v1 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Cross-species mapping study |
|---|---|
| Keywords | Psychedelics Compounds Psychedelic action Gene expression Genes Gene activity Genetics Gene activation Gene alteration Brain receptor 5ht2a Brain layers Human accelerated regions Brain evolution |
| Key points | Psychedelic gene expression patterns are associated with the 5HT2A receptor, cortical layers, and human accelerated regions. |
Abstract
Cross-species mapping of psychedelic gene expression reveals links to the 5HT2A receptor, cortical layers, and human accelerated regions