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Epidemiology of classic psychedelic substances: results from a Norwegian internet convenience sample

Tor-Morten Kvam, Malin V. Uthaug, Kristoffer A A Andersen, Birk Berggrav Refsum, Paula Aarseth Tunstad, Lowan Han Stewart, Henrik Børsting Jacobsen, Cato Grønnerød

Frontiers in Psychiatry November 13, 2023 DOI: 10.3389/fpsyt.2023.1287196 (opens in new tab)

Study at a glance

AI-extracted from the abstract
Characteristics Cross-sectional survey Peer reviewed
Sample size 770
Population Norwegian adults who have had a memorable experience after taking a classic psychedelic substance
Topics Addiction LSD Psilocybin
Keywords N,N-Dimethyltryptamine DMT Mental disorders Substance use disorders Psychedelics hallucinogens Entheogens Psychological wellbeing Mental wellness
Citations 21
Key findings Most participants reported improvements in self-perceived symptoms of mental disorders and substance use disorders after their psychedelic experience, though a small subset experienced persisting adverse reactions.

Abstract

Objective: In recent years, there has been a renewed interest in investigating the use of classic psychedelics such as psilocybin and lysergic acid diethylamide (LSD) in the treatment of mental disorders and substance use disorders. However, knowledge about the epidemiology of classic psychedelics in the Nordic countries is limited.

Methods: We recruited adult, Norwegian participants who have had a memorable experience after taking a classic psychedelic substance. They filled in an anonymous internet survey with 119 items covering matters related to recreational use of psychedelics using a secure, web-based application. Data are presented by using descriptive statistics (frequencies, means, and standard deviations).

Results: We recruited 841 participants, 770 (72% male; 88% 45 years or younger) of which were included in the data analysis. The intentions behind taking the psychedelic substance were mainly recreational (46.1%) or therapeutic (42.3%). Most participants reported that their most memorable experience was with psilocybin. As in modern era clinical trials, most participants were well-prepared before, did processing during, and did integration work after the experience, whereas only a minority were supported by a therapist. Self-perceived symptoms of various mental disorders and substance use disorders were prevalent in the sample. Most subjects reported improvements in their condition. Although adverse reactions were usually mild and short-lived, 4.2% lasted for 1 year or more. Persisting flashbacks were present for a year or more among 2.9% of the participants.

Conclusion: In this cross-sectional sample of Norwegian, self-selecting adults, we shed light on what characterizes the most memorable experience with a classic psychedelic substance, including short- and long-term risks and benefits. For the most part, the psychedelic experience led to improvements in self-perceived symptoms of mental disorders and substance use disorders. However, a small subset experienced persisting adverse reactions.

Comparable studies

Other cross-sectional and survey studies on LSD for addiction, most cited first.

Study Year Design Participants
User perceptions of the benefits and harms of hallucinogenic drug use: A web-based questionnaire study Users of hallucinogenic drugs who completed a web-based questionnaire 2010 Cross-sectional survey n = 600
Increased use of illicit drugs in a Dutch cluster headache population People with cluster headache in the Netherlands 2018 Cross-sectional study n = 756
Assessing The Readiness of Psychiatrists in Louisiana to Incorporate Psilocybin into Clinical Practice—Lessons Learned from a State Underrepresented in Clinical Psychedelic Research Registered psychiatrists in Louisiana 2025 Survey n = 49
The Relationship Between Psychedelic Use and Alcohol Use Disorder in a Nationally Representative Sample. Nationally representative sample of US adults 2025 Observational cross-sectional study n = 139,524
Perceived outcomes of psychedelic microdosing as self-managed therapies for mental and substance use disorders. International online respondents with current or past experience of psychedelic... 2020 Cross-sectional survey n = 1,102

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