Unlocking the biosynthesis of psychedelic-inspired indolethylamines.
Abhishek K. Sen, J. Andrew Jones
Trends in biochemical sciences March 1, 2024 DOI: 10.1016/j.tibs.2023.12.009 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Topics | 5-MeO-DMT DMT |
| Keywords | N-methylation Psychedelic indolethylamine Serotonin receptor binding Psychedelic-Compounds DMT Neuroscience serotonin Neurot Biochemistry |
| Citations | 2 |
| Key findings | RmNMT from the cane toad is a highly active and promiscuous tryptamine N-methyltransferase that produces DMT derivatives evaluated as potential treatments for mental health disorders. |
Abstract
A recent report by Chen et al. describes the discovery of RmNMT, a highly active and promiscuous tryptamine N-methyltransferase from the cane toad, Rhinella marina. N,N-dimethyltryptamine derivatives produced by this enzyme were then evaluated for their potential to serve as next-generation treatments for mental health disorders.
Comparable studies
Other experimental studies on 5-MeO-DMT, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Short term changes in the proteome of human cerebral organoids induced by 5-MeO-DMT. Human cerebral organoids | 2017 | Experimental study | |
| Bufo alvarius: a potent hallucinogen of animal origin. Bufo alvarius toad venom | 1994 | Experimental study | |
| Prospective examination of synthetic 5-methoxy-N,N-dimethyltryptamine inhalation: effects on salivary IL-6, cortisol levels, affect, and non-judgment Volunteers | 2019 | Within-subjects experimental study | n = 11 |
| Unmasking of a neonatal somatovesical reflex in adult cats by the serotonin autoreceptor agonist 5-methoxy-N,N-dimethyltryptamine. Adult cats | 1990 | Experimental study | n = 10 |
| Studies on the Mechanism of Action of Monoamine Oxidase: Metabolism of N,N-Dimethyltryptamine and N,N-Dimethyltryptamine-N-Oxide | 1962 | Experimental study |
Citations in the library
Cited by 3
- Pathway engineering for the biosynthesis of psychedelics Current Opinion in Biotechnology May 15, 2025
- Reconstituting a two-step pathway for N,N-dimethyltryptamine (DMT) biosynthesis in bacteria Metabolic Engineering Communications July 1, 2026
- Genome-based optimization of psilocybin and N,N-dimethyltryptamine biosynthetic pathways in E. coli using CRISPR-associated transposases Metabolic Engineering June 14, 2026
Cites 7
- Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors Science February 16, 2023
- Dark Classics in Chemical Neuroscience:N,N-Dimethyltryptamine (DMT) ACS Chemical Neuroscience July 23, 2018
- Synthesis and Characterization of 5-MeO-DMT Succinate for Clinical Use ACS Omega December 2, 2020
- “Biosynthesis of psilocybin and its nonnatural derivatives by a promiscuous psilocybin synthesis pathway in Escherichia coli” Biotechnology and Bioengineering June 20, 2023
- “In vivo biosynthesis of N,N-dimethyltryptamine, 5-MeO-N,N-dimethyltryptamine, and bufotenine in E. coli” Metabolic Engineering May 23, 2023
and 2 more in the library