Unlocking the biosynthesis of psychedelic-inspired indolethylamines.
Trends in biochemical sciences March 1, 2024 Abhishek K. Sen, J. Andrew Jones 2 citations
A recent report by Chen et al. describes the discovery of RmNMT, a highly active and promiscuous tryptamine N-methyltransferase from the cane toad, Rhinella marina. N,N-dimethyltryptamine derivatives produced by this enzyme were then evaluated for their potential to serve as next-generation treatments for mental health disorders.
DOI: 10.1016/j.tibs.2023.12.009 (opens in new tab)
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N-dimethyltryptamine
N-methylation
Psychedelic indolethylamine
Serotonin receptor binding
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