Lysergic acid diethylamide induces behavioral changes in Caenorhabditis elegans.
Isis M. Ornelas, Beatriz de S. Carrilho, Matheus Antonio V. de C. Ventura, Ivan Domith, Christiane M de V Silveira, Vanessa F Dos Santos, João M Delou, Francisco Moll, Henrique Marcelo G Pereira, Magno Junqueira, Hugo Aguilaniu, Stevens K. Rehen
Neuroscience Letters August 10, 2024 DOI: 10.1016/j.neulet.2024.137903 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Caenorhabditis elegans |
| Intervention | Lysergic acid diethylamide (LSD) |
| Topics | LSD Serotonin |
| Keywords | C. elegans Ser-4 receptor Behavioral science Serotonin 5- Psychedelics hallucinogens Psychedelic drugs Animal behavior locomotion Movement |
| Citations | 3 |
| Key findings | LSD reduces C. elegans locomotor speed, an effect partially mediated by the serotonergic receptors SER-1 and SER-4. |
Abstract
Lysergic acid diethylamide (LSD) is a synthetic psychedelic compound with potential therapeutic value for psychiatric disorders. This study aims to establish Caenorhabditis elegans as an in vivo model for examining LSD's effects on locomotor behavior. Our results demonstrate that LSD is absorbed by C. elegans and that the acute treatment reduces animal speed, similar to the role of endogenous serotonin. This response is mediated in part by the serotonergic receptors SER-1 and SER-4. Our findings highlight the potential of this nematode as a new experimental model in psychedelic research.
Comparable studies
Other experimental studies on LSD, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Neural correlates of the LSD experience revealed by multimodal neuroimaging. Human participants | 2016 | Experimental study | |
| Crystal structure of an LSD-bound human serotonin receptor | 2017 | Experimental study with structural biology and molecular dynamics simulations | |
| Lysergic Acid Diethylamide: Sensitive Neuronal Units in the Midbrain Raphe Midbrain neurons containing serotonin | 1968 | Experimental study | |
| Connectome-harmonic decomposition of human brain activity reveals dynamical repertoire re-organization under LSD. Human brain | 2017 | Experimental study | |
| LSD-Assisted Psychotherapy in Patients with Terminal Cancer Cancer patients | 1973 | Experimental study | n = 60 |
Citations in the library
Cited by 2
Cites 12
- Psychedelics Promote Structural and Functional Neural Plasticity Cell Reports June 1, 2018
- Safety and Efficacy of Lysergic Acid Diethylamide-Assisted Psychotherapy for Anxiety Associated With Life-threatening Diseases The Journal of Nervous and Mental Disease March 4, 2014
- Lysergic Acid Diethylamide-Assisted Therapy in Patients With Anxiety With and Without a Life-Threatening Illness: A Randomized, Double-Blind, Placebo-Controlled Phase II Study. Biological Psychiatry February 1, 2023
- Correlation between the potency of hallucinogens in the mouse head-twitch response assay and their behavioral and subjective effects in other species. Neuropharmacology May 1, 2020
- Psychedelic-inspired drug discovery using an engineered biosensor. Cell April 28, 2021
and 7 more in the library