Hallucinogenic agents as discriminative stimuli: a correlation with serotonin receptor affinities.
Richard A Glennon, R Young, John A. Rosecrans, M J Kallman
Psychopharmacology 1980 DOI: 10.1007/BF00432133 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Sample size | 24 |
| Population | Rats |
| Interventions | 5-methoxy-N N-dimethyltryptamine (5-OMe DMT) saline |
| Topics | Serotonin |
| Citations | 46 |
| Key findings | The hallucinogenic drug 5-OMe DMT's effects generalize to related tryptamine compounds in a dose-dependent manner, and the potency of these compounds correlates strongly with their affinity for serotonin receptors. |
Abstract
A choice between two levers in an operant chamber was used to train 24 rats, under a variable-interval 15 s schedule of sweetened milk reinforcement, to discriminate a hallucinogenic (psychotomimetic) agent, 5-methoxy-N,N-dimethyltryptamine (5-OMe DMT), from saline administration. The 5-OMe DMT stimulus generalized in a dose-related manner to each of 14 tryptamine related analogs. With the exception of one compound, the effective dose for the 5-OMe DMT response correlated highly (r = -0.86) with 5-HT receptor affinity (as determined using an isolated rat fundus preparation).
Comparable studies
Other preclinical and animal studies on serotonin, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Psilocybin induces rapid and persistent growth of dendritic spines in frontal cortex in vivo Mice | 2021 | Observational cohort | |
| Neurotoxicity of the psychedelic amphetamine, methylenedioxymethamphetamine. Rats (implied by typical neurochemical study context) | 1987 | Experimental study | |
| Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors In vitro and in vivo (rodent) models | 2023 | Experimental study | |
| 3,4-Methylenedioxymethamphetamine and 3,4-methylenedioxyamphetamine destroy serotonin terminals in rat brain: quantification of neurodegeneration by measurement of [3H]paroxetine-labeled serotonin uptake sites. Rat brain | 1987 | Animal experiment | |
| Comparison of the monoamine transporters from human and mouse in their sensitivities to psychostimulant drugs Human and mouse dopamine, norepinephrine, and serotonin transporters expressed in cells | 2006 | In vitro laboratory study |
Citations in the library
Cited by 27
- Psychedelics Promote Structural and Functional Neural Plasticity Cell Reports June 1, 2018
- Effects of N,N-Dimethyltryptamine on Rat Behaviors Relevant to Anxiety and Depression ACS Chemical Neuroscience April 17, 2018
- Dark Classics in Chemical Neuroscience:N,N-Dimethyltryptamine (DMT) ACS Chemical Neuroscience July 23, 2018
- Dihydrobenzofuran Analogues of Hallucinogens. 3. Models of 4-Substituted (2,5-Dimethoxyphenyl)alkylamine Derivatives with Rigidified Methoxy Groups Journal of Medicinal Chemistry 1996
- The roles of 5-HT1A and 5-HT2 receptors in the effects of 5-MeO-DMT on locomotor activity and prepulse inhibition in rats. Psychopharmacology December 1, 2006
and 22 more in the library
Cites 3
- Role of serotonin in the discriminative stimulus properties of mescaline Pharmacology, Biochemistry, and Behavior May 1, 1975
- Serotonin Receptor Binding Affinities of Several Hallucinogenic Phenylalkylamine and N,N-Dimethyltryptamine Analogues Journal of Medicinal Chemistry 1978
- Discriminative stimulus properties of mescaline: Mescaline or metabolite? Pharmacology, Biochemistry, and Behavior 1975