Analgesia induced by brief footshock: blockade by fenfluramine and 5-methoxy-N,N-dimethyltryptamine and prevention of blockade by 5-HT antagonists.
P H Hutson, M D Tricklebank, G Curzon
Brain Research November 21, 1983 DOI: 10.1016/0006-8993(83)90167-1 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Rats |
| Interventions | Fenfluramine 5-methoxy-N N-dimethyltryptamine (5-MeODMT) cyproheptadine methiothepin |
| Topics | 5-MeO-DMT DMT |
| Citations | 13 |
| Key findings | Brief footshock-induced analgesia in rats is not mediated by serotonin, but can be reduced by serotonin-enhancing drugs, an effect blocked by serotonin antagonists. |
Abstract
Analgesia induced by footshock (2 mA, 30 s) is decreased by the 5-HT releaser, fenfluramine, and the rapidly acting 5-HT agonist, 5-methoxy-N,N-dimethyltryptamine (5-MeODMT). These decreases are blocked by the 5-HT antagonists, cyproheptadine and methiothepin. However, the antagonists when given alone do not influence shock-induced analgesia. Therefore, analgesia induced by brief footshock in the absence of drugs may not involve 5-HT-dependent mechanisms even though it may be influenced by pharmacologically provoked changes of 5-HT release or by 5-MeODMT. This drug was also able to attenuate the analgesia after its induction, possibly reflecting a disruption of memory processes rather than of nociceptive mechanisms per se.