Acute and chronic effects of LSD and 5-MeODMT on raphe-evoked dorsal root potentials in the cat.
A A Larson
Life Sciences March 19, 1984 DOI: 10.1016/0024-3205(84)90092-4 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Cats |
| Interventions | LSD 5-MeODMT |
| Duration | Four consecutive daily injections for tolerance assessment |
| Topics | LSD 5-MeO-DMT |
| Citations | 3 |
| Key findings | LSD potentiates and 5-MeODMT inhibits the raphe-evoked dorsal root potential in cats, with tolerance developing to LSD's effect but not to 5-MeODMT's effect after repeated daily injections. |
Abstract
Both acute and chronic effects of lysergic acid diethylamide (LSD) and 5-methoxy-N,N-dimethyltryptamine (5-MeODMT) on the dorsal root potential (DRP), evoked by stimulation of the nucleus raphe magnus of the cat, were examined. Single injections of LSD potentiated while those of 5-MeODMT inhibited the raphe-evoked DRP. The electrophysiologic response produced by each drug correlates well in dosage and time-course with their reported behavioral effects. Following four consecutive daily injections of LSD, complete tolerance developed to the potentiating effect of LSD on this potential. A similar pretreatment schedule with 5-MeODMT failed to alter its acute inhibitory effect on the DRP. These results correlate well with the development of tolerance to the behavioral effects of LSD and 5-MeODMT. This system may thus provide a unique electrophysiological model to examine the effects of these drugs.
Comparable studies
Other experimental studies on 5-MeO-DMT, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Short term changes in the proteome of human cerebral organoids induced by 5-MeO-DMT. Human cerebral organoids | 2017 | Experimental study | |
| Bufo alvarius: a potent hallucinogen of animal origin. Bufo alvarius toad venom | 1994 | Experimental study | |
| Prospective examination of synthetic 5-methoxy-N,N-dimethyltryptamine inhalation: effects on salivary IL-6, cortisol levels, affect, and non-judgment Volunteers | 2019 | Within-subjects experimental study | n = 11 |
| Unmasking of a neonatal somatovesical reflex in adult cats by the serotonin autoreceptor agonist 5-methoxy-N,N-dimethyltryptamine. Adult cats | 1990 | Experimental study | n = 10 |
| Studies on the Mechanism of Action of Monoamine Oxidase: Metabolism of N,N-Dimethyltryptamine and N,N-Dimethyltryptamine-N-Oxide | 1962 | Experimental study |
Citations in the library
Cited by 2
Cites 6
- Inhibitory effect of chlorpromazine on the syndrome of hyperactivity produced by l‐tryptophan or 5‐methoxy‐N,N‐dimethyltryptamine in rats treated with a monoamine oxidase inhibitor British Journal of Pharmacology December 1, 1971
- CLINICAL REACTIONS AND TOLERANCE TO LSD IN CHRONIC SCHIZOPHRENIA The Journal of Nervous and Mental Disease September 1, 1955
- An Animal Behavior Model for Studying the Actions of LSD and Related Hallucinogens Science November 12, 1976
- Behavioral effects of 5-methoxy-N:N-dimethyltryptamine, other tryptamines, and LSD American Journal of Physiology-Legacy Content July 1, 1962
- Dissociations Between the Effects of LSD on Behavior and Raphe Unit Activity in Freely Moving Cats Science August 3, 1979
and 1 more in the library