Chronic phenytoin and the stereotyped motor response induced by 5-methoxy-N,N-dimethyltryptamine in rats.
Brain Research February 11, 1985 DOI: 10.1016/0006-8993(85)90052-6 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Animal experimental study Peer reviewed |
|---|---|
| Population | Male Sprague-Dawley rats |
| Interventions | Phenytoin 5-Methoxy-N N-dimethyltryptamine |
| Dose | PHT: 25 mg/kg (single injection); 5-MDMT: 1, 3 mg/kg and 1.7, 3.2 mg/kg |
| Duration | 20 consecutive days of phenytoin injections, with behavioral testing on days 21 and 28 |
| Topics | 5-MeO-DMT DMT |
| Citations | 1 |
| Key findings | Long-term phenytoin administration decreased the intensity of a stereotyped motor response induced by 5-MDMT at 3 mg/kg on day 21 but not on day 28, suggesting serotonin receptor subsensitivity. |
Abstract
Male Sprague-Dawley rats were injected with phenytoin (PHT) once a day for 20 consecutive days and then tested as to their response to 5-methoxy-N,N-dimethyltryptamine (5-MDMT), a 5-hydroxytryptamine (5-HT) agonist, at 1 and 3 mg/kg on days 21 and 28. It was found that long-term PHT administration decreased the intensity of a stereotyped motor response induced by 5-MDMT (3 mg/kg) on day 21 but not on day 28. A single injection of PHT (25 mg/kg) did not modify the motor response induced by 5-MDMT (3 mg/kg) on day 21 but not on day 28. A single injection of PHT (25 mg/kg) did not modify the motor response induced by 5-MDMT (1.7, 3.2 mg/kg). It is suggested that PHT increases the functional availability of 5-HT before its receptors, and thereby causes 5-HT receptor subsensitivity.