11C-labeling of indolealkylamine alkaloids and the comparative study of their tissue distributions.
T Takahashi, K Takahashi, Tatsuo Ido, Kazuhiko Yanai, Ren Iwata, Kiichi Ishiwata, S Nozoe
The International journal of applied radiation and isotopes December 1, 1985 DOI: 10.1016/0020-708x(85)90257-1 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Rats |
| Citations | 27 |
| Key findings | [11C]DMT had the highest radiochemical yield and brain uptake among the five labeled compounds, making it the preferred radiopharmaceutical for studying serotonin action in the brain. |
Abstract
Five indolealkylamines (N,N-dimethyltryptamine, N-methyltryptamine, bufotenine, O-methylbufotenine, N,N,N-trimethyltryptamine iodide) were labeled with 11C by use of 11CH3I. The labeled compounds were synthesized with a radiochemical yield of 2-50% (based on trapped 11CH3I) in 20-35 min with radiochemical purities of more than 92%. The tissue distributions of these labeled compounds were investigated in rats. In all cases, the accumulations in the liver, lung and small intestine were high. [11C]DMT and [11C]OMB also accumulated to a large extent in the brain, where their accumulation was retained. Brain uptake of three other radiopharmaceuticals was low. [11C]DMT is the radiopharmaceutical of choice for the study of the serotonin action mechanism in the brain, because it has the highest radiochemical yield and the highest brain uptake of these 11C-labeled compounds.
Citations in the library
Cited by 21
- The neural basis of psychedelic action. Nature Neuroscience October 24, 2022
- Neuropharmacology of N,N-dimethyltryptamine Brain Research Bulletin April 30, 2016
- Dimethyltryptamine and other hallucinogenic tryptamines exhibit substrate behavior at the serotonin uptake transporter and the vesicle monoamine transporter. Journal of Neural Transmission September 12, 2009
- Dark Classics in Chemical Neuroscience:N,N-Dimethyltryptamine (DMT) ACS Chemical Neuroscience July 23, 2018
- A possibly sigma-1 receptor mediated role of dimethyltryptamine in tissue protection, regeneration, and immunity. Journal of Neural Transmission April 26, 2013
and 16 more in the library
Cites 2
- Isolation of Psilocybin From Psilocybe argentipes and Its Determination in Specimens of Some Mushrooms Journal of Natural Products May 1, 1981
- Carbon 11 labeling of the psychoactive drug o-methyl-bufotenine and its distribution in the animal organism. European journal of nuclear medicine April 1, 1978