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In vivo kinetics and displacement study of a carbon-11-labeled hallucinogen, N,N-[11C]dimethyltryptamine

Kazuhiko Yanai, Tatsuo Ido, Kiichi Ishiwata, Jun Hatazawa, Toshihiro Takahashi, Ren Iwata, T Matsuzawa

European Journal of Nuclear Medicine and Molecular Imaging July 1, 1986 DOI: 10.1007/bf00276707 (opens in new tab)

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Study at a glance

AI-extracted from the abstract
Characteristics Experimental study Peer reviewed
Population Rat brain and dog brain
Interventions [11C]DMT Pargyline 5-methoxy-N N-dimethyltryptamine
Dose very low dose
Topics Serotonin 5-MeO-DMT DMT
Keywords Radioligand Hallucinogen Pargyline Receptor In vivo Monoamine oxidase inhibitor Putamen Pharmacology Biophysics Biochemistry
Citations 2
Key findings DMT binds specifically to serotonin receptors, with pargyline pretreatment enhancing its localization in receptor-rich fractions and 5-methoxy-N,N-dimethyltryptamine displacing about 20% of the radioligand from receptors in dog brain.

Abstract

The endogenous hallucinogen, N,N-dimethyltryptamine (DMT), was labeled with carbon-11 and its regional distribution in rat brain studied. [11C]DMT showed higher accumulation in the cerebral cortex, caudate putamen, and amygdaloid nuclei. Studies of the subcellular distribution of [11C]DMT revealed the specific localization in the fractions enriched with serotonin receptors only when a very low dose was injected into rats. The proportions of the radioactivity in receptor-rich fractions were greatly enhanced by pretreatment with the monoamine oxidase inhibitor, pargyline. Specific binding of [11C]DMT to serotonin receptors in dog brain was demonstrated by a positron emission tomographic study in which 5-methoxy-N,N-dimethyltryptamine caused approximately 20% displacement of the radioligand from the receptors.

Comparable studies

Other experimental studies on DMT, most cited first.

Study Year Design Participants
Short term changes in the proteome of human cerebral organoids induced by 5-MeO-DMT. Human cerebral organoids 2017 Experimental study
Prospective examination of synthetic 5-methoxy-N,N-dimethyltryptamine inhalation: effects on salivary IL-6, cortisol levels, affect, and non-judgment Volunteers 2019 Within-subjects experimental study n = 11
Metabolism and disposition of N,N‐dimethyltryptamine and harmala alkaloids after oral administration of ayahuasca Healthy male volunteers 2012 Observational pharmacokinetic study n = 10
Unmasking of a neonatal somatovesical reflex in adult cats by the serotonin autoreceptor agonist 5-methoxy-N,N-dimethyltryptamine. Adult cats 1990 Experimental study n = 10
Studies on the Mechanism of Action of Monoamine Oxidase: Metabolism of N,N-Dimethyltryptamine and N,N-Dimethyltryptamine-N-Oxide 1962 Experimental study

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Serotonin 5-MeO-DMT DMT