Refractory CRPS pain treated with psilocybin: A case report
David S Jevotovsky, Harman Chopra, Court Wing, Carlton J Spotswood, Joel Castellanos
Clinical Case Reports September 1, 2024 DOI: 10.1002/ccr3.9421 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Case study Case report Peer reviewed |
|---|---|
| Sample size | 1 |
| Population | A patient with refractory complex regional pain syndrome |
| Intervention | Psilocybin |
| Topics | Psilocybin Psychedelic-assisted therapy |
| Keywords | Medical research Chronic pain Psychedelics Pain management Crps |
| Citations | 9 |
| Key findings | Psilocybin provided significant pain relief and functional improvement in a patient with treatment-resistant CRPS. |
Abstract
Key Clinical Message Psilocybin shows promise as a treatment for CRPS, offering significant pain relief and functional improvement in a patient with refractory symptoms. This case highlights the need for further research into psilocybin's efficacy and optimal dosing for chronic pain management.
Comparable studies
Other case reports and case series on psilocybin and psychedelic-assisted therapy, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Prolonged adverse effects from repeated psilocybin use in an underground psychedelic therapy training program: a case report | 2025 | Case study | |
| Suicide of a patient shortly after psilocybin-assisted psychedelic therapy: A case report 60-year-old man with recurrent depression and history of delusions | 2025 | Case study | n = 1 |
| Underground small-group therapy of treatment-resistant depression and complex post-traumatic stress disorder (C-PTSD) with psilocybin—A retrospective case study A woman in her early forties with early complex trauma and treatment-resistant depression | 2023 | Case report | n = 1 |
| Psilocybin-assisted psychotherapy for methamphetamine dependence: a case report involving daily methamphetamine use A 36-year-old transwoman who was a daily methamphetamine user | 2024 | Case study | n = 1 |
| Long‐COVID symptoms improved after MDMA and psilocybin therapy: A case report 41-year-old fully vaccinated female with Long-COVID syndrome | 2024 | Case report | n = 1 |
Citations in the library
Cited by 8
- Psilocybin as a novel treatment for chronic pain British Journal of Pharmacology November 29, 2024
- Ethical Considerations Regarding Psychedelics for Clinical Pain Research. Journal of Pain Research 2024
- Psilocybin, From Ancestral Use to Therapeutic Potential: A Multidimensional Review of Its Pharmacological Basis and Current Perspectives Human Psychopharmacology: Clinical and Experimental September 1, 2026
- Psilocybin in Older Adults: Therapeutic Opportunities in Inflammation-Driven Disorders of Aging-From Depression to Neurodegeneration. International Journal of Molecular Sciences May 9, 2026
- Psilocybin and Chronic Pain: A New Perspective for Future Pain Therapists? Medical Sciences November 20, 2025
and 3 more in the library
Cites 7
- Psychedelic Drug Legislative Reform and Legalization in the US JAMA Psychiatry December 7, 2022
- Exploratory Controlled Study of the Migraine-Suppressing Effects of Psilocybin. Neurotherapeutics 2021
- Exploratory investigation of a patient‐informed low‐dose psilocybin pulse regimen in the suppression of cluster headache: Results from a randomized, double‐blind, placebo‐controlled trial Headache: The Journal of Head and Face Pain November 1, 2022
- Relief from intractable phantom pain by combining psilocybin and mirror visual-feedback (MVF) Neurocase March 4, 2018
- Microdosing psilocybin for chronic pain: a case series Pain September 5, 2022
and 2 more in the library