Effects of ibogaine on responding maintained by food, cocaine and heroin reinforcement in rats.
Psychopharmacology February 1, 1995 S I Dworkin, S Gleeson, D Meloni et al. 49 citations
The effects of ibogaine (40 and 80 mg/kg, i.p.), an indole alkaloid proposed for the treatment of drug abuse, were determined in three different groups of rats responding under an FR10 schedule of food, cocaine or heroin reinforcement. Ibogaine (80 mg/kg, i.p.) given 60 min before the start of the session resulted in a 97% decrease in the number of ratios completed under the food reinforcement...