Differential effects of ibogaine on behavioural and dopamine sensitization to cocaine.
Karen K. Szumlinski, Isabelle M Maisonneuve, Stanley D Glick
European Journal of Pharmacology June 16, 2000 DOI: 10.1016/s0014-2999(00)00325-3 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Rats |
| Interventions | Ibogaine Cocaine |
| Dose | 40 mg/kg i.p. ibogaine; 20 mg/kg cocaine challenge; 5 x 15 mg/kg cocaine for sensitization |
| Topics | Ibogaine |
| Keywords | Addiction treatment Cocaine addiction Neuroadaptation |
| Citations | 19 |
| Key findings | Ibogaine pretreatment reversed the expression of cocaine-induced dopamine sensitization in the nucleus accumbens without affecting the dopamine response to acute cocaine. |
Abstract
To investigate a possible basis for the proposed anti-addictive property of ibogaine, the effects of ibogaine (40 mg/kg, i.p., 19 h earlier) on the expression of sensitization induced by cocaine were investigated. Ibogaine pretreatment potentiated the increase in the stereotypic effects of a cocaine challenge (20 mg/kg) in both sensitized (5 x 15 mg/kg, i.p.) and acutely treated rats. However, while ibogaine pretreatment did not significantly alter the dopamine response in the nucleus accumbens to acute cocaine, it abolished the expression of cocaine-induced dopamine sensitization. This result demonstrates that ibogaine pretreatment can reverse one of the neuroadaptations produced by chronic cocaine administration, an effect that may contribute to its putative anti-addictive property.