Effects of ibogaine and noribogaine on phosphoinositide hydrolysis.
Brain Research August 26, 1996 DOI: 10.1016/0006-8993(96)00688-9 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Laboratory experiment Peer reviewed |
|---|---|
| Population | Rat striatal and hippocampal slices |
| Interventions | ibogaine noribogaine |
| Topics | Ibogaine |
| Citations | 7 |
| Key findings | Noribogaine, but not ibogaine, stimulates phosphoinositide hydrolysis in rat brain slices independently of neurotransmitter release. |
Abstract
The effects of the antiaddictive compound, ibogaine, and its primary metabolite, noribogaine (12-hydroxyibogamine), on phosphoinositide hydrolysis were investigated. Although ibogaine did not alter phosphoinositide turnover in either striatal or hippocampal slices, noribogaine elicited a concentration-dependent increase in the generation of [3H]inositol phosphates. This stimulation was not altered by inclusion of tetrodotoxin, cadmium or omega-conotoxin indicating that the increased production of [3H]inositol phosphates was not secondary to a release of one or more neurotransmitters. The present study indicates a stimulation of phosphoinositide hydrolysis by noribogaine may be involved in the behavioral effects of ibogaine.