The effects of noribogaine and harmaline in rats trained with ibogaine as a discriminative stimulus.
Scott Helsley, R A Rabin, Jerrold C Winter
Life Sciences 1997 DOI: 10.1016/s0024-3205(96)00703-5 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Animal discrimination study Peer reviewed |
|---|---|
| Population | Fischer-344 rats |
| Interventions | Ibogaine harmaline |
| Dose | 10.0 mg/kg ibogaine; ED50 4.6 mg/kg |
| Duration | Pretreatment times up to 8 hours |
| Topics | Ibogaine |
| Citations | 13 |
| Key points | Ibogaine's discriminative stimulus effects in rats peak at 60 minutes, show partial generalization to its metabolite noribogaine and full generalization to harmaline. |
Abstract
In the present investigation, Fischer-344 rats were trained to discriminate 10.0 mg/kg of ibogaine from water using a pretreatment time of 60 minutes. Analysis of dose response data generated an ED50 of 4.6 mg/kg. The time course of the ibogaine (10.0 mg/kg) cue was also determined. The stimulus reached a maximum level of 94% ibogaine-appropriate responding at the 60-min pretreatment time. This was followed by a time-dependent decrease in ibogaine-appropriate responding. At a pretreatment time of 8 hrs only 6.4% drug-appropriate responding was observed. In substitution experiments, intermediate generalization was observed with a metabolite of ibogaine, 12-hydroxyibogamine [noribogaine] (71.6%) whereas complete generalization was seen with harmaline (83.5%).
Comparable studies
Other preclinical and animal studies on ibogaine, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Noncompetitive Functional Inhibition at Diverse, Human Nicotinic Acetylcholine Receptor Subtypes by Bupropion, Phencyclidine, and Ibogaine TE671/RD cells (human muscle-type nAChR) and SH-SY5Y neuroblastoma cells (human... | 1999 | In vitro study | |
| Degeneration of Purkinje cells in parasagittal zones of the cerebellar vermis after treatment with ibogaine or harmaline. Ibogaine- or harmaline-treated rats | 1993 | Experimental animal study | |
| Effects and aftereffects of ibogaine on morphine self-administration in rats. Rats | 1991 | Preclinical experimental study | |
| Effects of iboga alkaloids on morphine and cocaine self-administration in rats: relationship to tremorigenic effects and to effects on dopamine release in nucleus accumbens and striatum. Rats | 1994 | Experimental study | |
| Glial Cell Line-Derived Neurotrophic Factor Mediates the Desirable Actions of the Anti-Addiction Drug Ibogaine against Alcohol Consumption Rats | 2005 | Experimental study |
Citations in the library
Cited by 10
- Noribogaine generalization to the ibogaine stimulus: correlation with noribogaine concentration in rat brain. Neuropsychopharmacology July 1, 1999
- EEG Gamma Band Alterations and REM-like Traits Underpin the Acute Effect of the Atypical Psychedelic Ibogaine in the Rat. ACS Pharmacology & Translational Science April 9, 2021
- Effects of chronic ibogaine treatment on cerebellar Purkinje cells in the rat. Brain Research June 13, 1997
- Ibogaine and Noribogaine: Comparing Parent Compound to Metabolite CNS Drug Reviews September 1, 2000
- Stimulus control by 5-methoxy-N,N-dimethyltryptamine in wild-type and CYP2D6-humanized mice. Pharmacology, Biochemistry, and Behavior September 1, 2011
and 5 more in the library
Cites 16
- Effects and aftereffects of ibogaine on morphine self-administration in rats. European Journal of Pharmacology April 3, 1991
- Effects of iboga alkaloids on morphine and cocaine self-administration in rats: relationship to tremorigenic effects and to effects on dopamine release in nucleus accumbens and striatum. Brain Research September 19, 1994
- Inhibitory effects of ibogaine on cocaine self-administration in rats. European Journal of Pharmacology September 14, 1993
- A preliminary investigation of ibogaine: case reports and recommendations for further study. Journal of Substance Abuse Treatment 1994
- Attenuation of alcohol intake by ibogaine in three strains of alcohol-preferring rats. Pharmacology, Biochemistry, and Behavior November 1, 1995
and 11 more in the library