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Schizophr Res

ISSN 0920-9964; 1573-2509;

7 papers in the library · 510 citations · publishing 2005-2026

Papers

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From dopamine to salience to psychosis--linking biology, pharmacology and phenomenology of psychosis.

Schizophr Res November 1, 2005 Shitij Kapur, Romina Mizrahi, Ming Li 510 citations

How does an excess in a neurochemical lead someone to being paranoid about the intentions of their neighbour? And why does blocking a dopamine receptor improve this symptom? In this article we present a heuristic framework which attempts to link the biology, phenomenology and pharmacology of psychosis. Focussing on dopamine's role in reward prediction and motivational salience we propose that...