Pathway engineering for the biosynthesis of psychedelics
Current Opinion in Biotechnology May 15, 2025 Zachary N. Abrahms, Abhishek K. Sen, J. Andrew Jones 2 citations
Naturally occurring psychoactive compounds have been used for cultural and ethnomedical purposes for centuries. Several more such molecules continue to be chemically synthesized, exhibiting a wide range of potency, therapeutic, and hallucinogenic effects. Promising clinical data and a renewed interest in understanding the cellular mechanisms of action have inspired synthetic biology efforts to...