In vivo kinetics and displacement study of a carbon-11-labeled hallucinogen, N,N-[11C]dimethyltryptamine
European Journal of Nuclear Medicine and Molecular Imaging July 1, 1986 Kazuhiko Yanai, Tatsuo Ido, Kiichi Ishiwata et al. 2 citations
The endogenous hallucinogen N,N-dimethyltryptamine (DMT), labeled with carbon-11, accumulates preferentially in the cerebral cortex, caudate putamen, and amygdaloid nuclei of rat brain. Subcellular distribution studies show specific localization in fractions enriched with serotonin receptors only when a very low dose is injected. Pretreatment with the monoamine oxidase inhibitor pargyline greatly enhances the proportion of radioactivity in receptor-rich fractions. In dog brain, positron emission tomography demonstrates specific binding of [11C]DMT to serotonin receptors, with 5-methoxy-N,N-dimethyltryptamine causing approximately 20% displacement of the radioligand from receptors.