Journal of Chromatography B Biomedical Sciences and Applications
December 1, 2001
J Canezin, A Cailleux, Alain Turcant et al.
62 citations
A liquid chromatographic procedure with electrospray ionization tandem mass spectrometric detection has been developed and validated for LSD and iso-LSD determination. A one-step liquid-liquid extraction on 1 ml blood or urine was used. The lower limit for quantitative determination was 0.02 microg/l for LSD and iso-LSD. The analytical procedure has been applied in two positive cases (case 1:...
Journal of Chromatography B Biomedical Sciences and Applications
March 1, 1999
Gregory K. Poch, K. L. Klette, Domingo A. Hallare et al.
50 citations
Seventy-four urine specimens previously found to contain lysergic acid diethylamide (LSD) by gas chromatography-mass spectrometry (GC-MS) were analyzed by a new procedure for the LSD metabolite 2-oxo-3-hydroxy-LSD (O-H-LSD) using a Finnigan LC-MS-MS system. This procedure proved to be less complex, shorter to perform and provides cleaner chromatographic characteristics than the method currently...
Journal of Chromatography B Biomedical Sciences and Applications
May 1, 1998
Hiltrud Lindenblatt, Edda Krämer, Petra Holzmann-Erens et al.
92 citations
Two modifications of the HPLC-ED method with respect to extraction procedure used have been developed for psilocin, the active metabolite of psilocybin, in human plasma using either liquid-liquid extraction (LLE) or automated on-line solid-phase extraction (on-line SPE). Each type of the sample preparation required a different HPLC system followed by electrochemical detection at 650 to 675 mV....
Journal of Chromatography B Biomedical Sciences and Applications
July 1, 1997
Stig Pedersen-Bjergaard, Ellen Sannes, Knut Rasmussen et al.
28 citations
A capillary zone electrophoretic (CZE) method was developed for the rapid determination of psilocybin in Psilocybe semilanceata. Following a simple two step extraction with 3.0+2.0 ml methanol, the hallucinogenic compound was effectively separated from matrix components by CZE utilizing a 10 mM borate-phosphate running buffer adjusted to pH 11.5. The identity of psilocybin was confirmed by...
Journal of Chromatography B Biomedical Sciences and Applications
September 1, 1992
Chad C. Nelson, Rodger L. Foltz
46 citations
Continued illicit use of the potent psychedelic drug lysergic acid diethylamide (LSD) has stimulated efforts to develop effective analytical methods for detection of the drug and its metabolites in body fluids from suspected LSD users. Recently reported methods based on gas and liquid chromatography, combined with single- and multiple-stage mass spectral analysis, now permit accurate detection...