Analytical Chemistry
April 29, 2025
Zhongbao Han, Zhongyu Zhao, Meiyun Pan et al.
3 citations
A novel method for rapid and sensitive illicit drug screening in biofluids has been developed by employing a paper-based sample collection coupled with ultrasonic desorption-assisted low-temperature plasma ionization mass spectrometry (PBS-LTPI-MS). For optimization, key experimental parameters, such as geometry coordinates, angle, and plasma intensity, were fine-tuned using ketamine as the...
Analytical Chemistry
February 11, 2025
Yun Wu, Mei Li, Ruidong Liu et al.
6 citations
Globally, drug-impaired driving fatalities now exceed those from drunk driving, urging the need for on-site and roadside detection methods. In this study, a photothermal desorption and reagent-assisted low-temperature plasma ionization miniature ion trap mass spectrometer (PDRA-LTP-ITMS) was developed for on-site detection of drug-impaired driving. The pseudomultiple reaction monitoring (MRM)...
Analytical Chemistry
November 14, 2019
Eline Pottie, Annelies Cannaert, Katleen van Uytfanghe et al.
29 citations
Classic or serotonergic hallucinogens comprise the third largest number of reported new psychoactive substances (NPS), according to the United Nations Office on Drugs and Crime. While being structurally very divergent, they share activation of the serotonin 2A receptor (5-HT2AR), a G protein-coupled receptor, as their main pharmacological mechanism. Here, we report on the development of a...
Analytical Chemistry
February 7, 2017
Ana Flávia B. Andrade, Samuel Kasahun Mamo, Jose Gonzalez-Rodriguez
The NBOMe derivatives are phenethylamines derived from the 2C class of hallucinogens. Only a few human pharmacologic studies have been conducted on these drugs, and several cases of intoxication and deaths have been reported. Presently, NBOMe are not a part of the routine drugs-of-abuse screening procedure for many police forces, and there are no rapid immunoassay screening tests that can...
Analytical Chemistry
1996
Jianyi Cai, Jack D. Henion
112 citations
An on-line immunoaffinity extraction-coupled column capillary liquid chromatography/tandem mass spectrometry (IAE/LC/LC/MS/MS) method is described. The system involves three columns, a 2.1-mm-i.d. protein G immunoaffinity column with noncovalently immobilized antibody specific to the analytes of interest, a packed capillary trapping column, and a packed capillary analytical column. With use of...
Analytical Chemistry
July 15, 1992
Chad C. Nelson, Rodger L. Foltz
64 citations
Procedures for detection and quantitation of lysergic acid diethylamide (LSD), iso-LSD, and N-demethyl-LSD by capillary chromatography/tandem mass spectrometry (GC/MS/MS) are presented. Several methods for derivatization, sample introduction, and ionization, in combination with mass spectrometry/mass spectrometry (MS/MS), have been evaluated for overall ionization efficiency and product-ion...
Analytical Chemistry
July 15, 1988
Hyun Kyoon Lim, David M. Andrenyak, Paula Francom et al.
68 citations
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTQuantification of LSD and N-demethyl-LSD in urine by gas chromatography/resonance electron capture ionization mass spectrometryHeng Keang. Lim, David. Andrenyak, Paula. Francom, Rodger L. Foltz, and Reese T. JonesCite this: Anal. Chem. 1988, 60, 14, 1420–1425Publication Date (Print):July 15, 1988Publication History Published online1 May 2002Published...