Research published in Pharmacology, biochemistry, and behavior

Prophylactic effects of arketamine, but not hallucinogenic psychedelic DOI nor non-hallucinogenic psychedelic analog lisuride, in lipopolysaccharide-treated mice and mice exposed to chronic restrain stress.

Pharmacology, biochemistry, and behavior December 1, 2023 Guilin Liu, Li Ma, Youge Qu et al. 16 citations

Anesthetic ketamine and classical psychedelics that act as 5-hydroxytryptamine-2A receptor (5-HT2AR) agonists demonstrated rapid and sustained antidepressant actions in patients with treatment-resistant depression. The new antidepressant arketamine is reported to cause long-lasting prophylactic effects in lipopolysaccharide (LPS)-treated mice and mice exposed to chronic restrain stress (CRS)....

DOI: 10.1016/j.pbb.2023.173659 Full text Arketamine Chronic stress Inflammation Prophylactic +1

Ketamine retards recovery from reward downshift and supports conditioned taste aversion.

Pharmacology, biochemistry, and behavior October 28, 2023 Antonio D R Agüera, Clara Cándido, Rocío Donaire et al. 4 citations

Ketamine is a noncompetitive N-methyl-d-aspartate (NMDA) receptor antagonist with antidepressant, anxiolytic, and memory effects in clinical and preclinical studies. The present studies investigated the behavioral effects of ketamine in animals exposed to a consummatory successive negative contrast (cSNC) task involving unexpected reward downshift, negative emotion (frustration), and aversive...

DOI: 10.1016/j.pbb.2023.173671 Full text Conditioned taste aversion Frustration Motivational summation Reward downshift +5

Experimenter administered Δ9-THC decreases nicotine self-administration in a rat model.

Pharmacology, biochemistry, and behavior October 2023 Antony D Abraham, Jenny L Wiley, Julie A Marusich

The co-use of nicotine and cannabis has been steadily rising in the United States. Rodent studies suggest that delta-9-tetrahydrocannabinol (THC) could increase addictive qualities of nicotine, but whether repeated THC exposure alters self-administration of nicotine has not been tested. We hypothesized that THC would increase the reinforcing effects of nicotine and alter nicotine intake. Adult...

DOI: 10.1016/j.pbb.2023.173632 Full text Cannabis Co-abuse Delta-9-tetrahydrocannabinol Nicotine +2

FABP5 is important for cognitive function and is an important regulator of the physiological effects and pharmacokinetics of acute Δ9 tetrahydrocannabinol inhalation in mice.

Pharmacology, biochemistry, and behavior October 2023 Samantha L Penman, Nicole M Roeder, Erin C Berthold et al.

Fatty acid binding protein 5 (FABP5) interacts with the endocannabinoid system in the brain via intracellular transport of anandamide, as well as Δ9-tetrahydrocannabinol (THC), the main psychoactive component of cannabis. Previous work has established the behavioral effects of genetic deletion of FABP5, but not in the presence of THC. The present study sought to further elucidate the role of...

DOI: 10.1016/j.pbb.2023.173633 Full text Endocannabinoid system Locomotion Memory Pharmacokinetics +1

Retigabine promotes ketamine's antidepressant effect in the forced swim test in male and female C57BL/6J mice.

Pharmacology, biochemistry, and behavior September 1, 2023 Yixue Qin, Haoxuan Li, Yuqi Zhang et al. 6 citations

Ketamine has been increasingly used as a rapid-onset antidepressant in specific clinical settings. However, as a psychedelic reagent, the potential of physical and psychological dependence limits its clinical use. Here, we added retigabine, a KCNQ channel opener, as an adjunctive treatment to observe its effect on ketamine's antidepressant property in a forced swim test in both male and female...

DOI: 10.1016/j.pbb.2023.173590 Full text Ketamine Major depressive disorder Forced swim test Retigabine

D-cycloserine is not susceptible to self-administration using an intravenous self-administration model in male ketamine-habituated Sprague-Dawley rats.

Pharmacology, biochemistry, and behavior June 2023 Michael T Sapko, Taleen Hanania, Qing Chang et al.

N-methyl-d-aspartate receptor (NMDAR) antagonist antidepressants have known potential for abuse liability. The aim of this study was to evaluate the abuse liability of D-cycloserine (DCS), using a self-administration paradigm in which DCS was tested for its efficacy in substituting for ketamine in ketamine-dependent rats. A standard intravenous self-administration study was conducted in male...

DOI: 10.1016/j.pbb.2023.173586 Full text Esketamine Abuse liability D-cycloserine Nmda receptor +1

Repeated dextromethorphan administration in adolescent rats produces long-lasting behavioral alterations.

Pharmacology, biochemistry, and behavior June 1, 2023 M L Shawn Bates, Keith A Trujillo

Initiation of non-medical dextromethorphan (DXM) use often occurs in adolescence, yet little is known about the consequences when use begins during this developmental period. The current experiments examined the acute response and the effects of repeated exposure to DXM in adolescence on behavior in adulthood. We examined locomotor activity, locomotor sensitization, and cognitive function, in...

DOI: 10.1016/j.pbb.2023.173581 Full text Addiction Ketamine Adolescence Cognition +4

Differentially regulated targets in the fast-acting antidepressant effect of (R)-ketamine: A systems biology approach.

Pharmacology, biochemistry, and behavior February 2023 Ellen Scotton, Pedro Lenz Casa, Fernanda Pessi De Abreu et al.

Approximately two-thirds of patients with major depressive disorder (MDD) fail to respond to conventional antidepressants, suggesting that additional mechanisms are involved in the MDD pathophysiology. In this scenario, the glutamatergic system represents a promising therapeutic target for treatment-resistant depression. To our knowledge, this is the first study using semantic approach with...

DOI: 10.1016/j.pbb.2023.173523 Full text R-ketamine Glutamatergic synapse Ketamine enantiomers Molecular targets +2

Methylone pre-exposure differentially impacts the aversive effects of MDPV and MDMA in male and female Sprague-Dawley rats: Implications for abuse vulnerability.

Pharmacology, biochemistry, and behavior October 2022 Hayley N Manke, Katharine H Nelson, Shihui Huang et al.

Polydrug use is well documented in synthetic cathinone users, although the consequences of such use are not well characterized. In pre-clinical research, a pre-exposure to a drug has been reported to attenuate the aversive effects of other drugs which has implications for their abuse potential. The goal of the present study was to investigate the impact of pre-exposure to the synthetic...

DOI: 10.1016/j.pbb.2022.173470 Full text MDMA Mdpv Methylone Polydrug use +2

Rewarding and reinforcing effects of two dissociative-based new psychoactive substances, deschloroketamine and diphenidine, in mice.

Pharmacology, biochemistry, and behavior February 1, 2022 Jin Mook Kim, Boreum Han, Hyun Kyu Min et al. 4 citations

Dissociative-based new psychoactive substances (NPSs) are increasingly available through the Internet, and public health problems related to the recreational use of these substances have been increasing globally. Two such NPSs are deschloroketamine and diphenidine, which are primarily used recreationally as ketamine substitutes. However, there is little scientific evidence to describe the...

DOI: 10.1016/j.pbb.2022.173333 Full text Conditioned place preference Dependence liability Deschloroketamine Diphenidine +2

High ambient temperature increases the toxicity and lethality of 3,4-methylenedioxymethamphetamine and methcathinone.

Pharmacology, biochemistry, and behavior May 2020 Yu Chen, Huyen T N Tran, Yasir H Saber et al.

Methylenedioxymethamphetamine (MDMA) and methcathinone (MCAT) are abused psychostimulant drugs that produce adverse effects in human users that include hepatotoxicity and death. Recent work has suggested a connection between hepatotoxicity, elevations in plasma ammonia, and brain glutamate function for methamphetamine (METH)-induced neurotoxicity. These experiments investigated the effect of...

DOI: 10.1016/j.pbb.2020.172912 Full text Methylenedioxymethamphetamine Hepatotoxicity Hyperthermia Hypothermia +3

Synthetic psychoactive cathinones: hypothermia and reduced lethality compared to methamphetamine and methylenedioxymethamphetamine.

Pharmacology, biochemistry, and behavior April 2020 Dawn E Muskiewicz, Federico Resendiz-Gutierrez, Omar Issa et al.

Synthetic psychoactive cathinones (SPCs) are drugs with psychostimulant and entactogenic properties like methamphetamine (MA) and 3,4-methylenedioxymethamphetamine (MDMA). Despite clinical reports of human overdose, it remains to be determined if SPCs have greater propensity for adverse effects than MA or MDMA. To determine whether the SPCs cathinone (CAT), methcathinone (MCAT), mephedrone...

DOI: 10.1016/j.pbb.2020.172871 Full text Methylenedioxymethamphetamine Lethality Mephedrone Methcathinone +3

Cannabinoids, interoception, and anxiety.

Pharmacology, biochemistry, and behavior May 1, 2019 Allyson K Andrade, Briana Renda, Jennifer E Murray

The use of cannabis is rapidly gaining legal status across North America. Such dramatic legislative shifts have prompted an urgency in elucidating the stimulus effects of cannabis consumption. Cannabis use, though relatively safe compared to other drugs of abuse, has been associated with greater risk of mental health disorders, possibly via its primary psychoactive constituent,...

DOI: 10.1016/j.pbb.2019.03.006 Full text Anxiety Cannabis Tetrahydrocannabinol Conditioning +2

Differences between adolescents and adults in the acute effects of PCP and ketamine and in sensitization following intermittent administration.

Pharmacology, biochemistry, and behavior June 1, 2017 Angelica Rocha, Nigel Hart, Keith A Trujillo

Adolescence is a phase of development during which many physiological and behavioral changes occur, including increased novelty seeking and risk taking. In humans, this is reflected in experimentation with drugs. Research demonstrates that drug use that begins during adolescence is more likely to lead to addiction than drug use that begins later in life. Despite this, relatively little is known...

DOI: 10.1016/j.pbb.2017.04.007 Full text Addiction Ketamine Locomotor Phencyclidine +1

Effects of the psychotomimetic benzomorphan N-allylnormetazocine (SKF 10,047) on prepulse inhibition of startle in mice.

Pharmacology, biochemistry, and behavior September 1, 2016 Adam L. Halberstadt, James Hyun, Michael A Ruderman et al.

N-allylnormetazocine (NANM; SKF 10,047) is a benzomorphan opioid that produces psychotomimetic effects. (+)-NANM is the prototypical agonist for the sigma-1 (σ1) receptor, and there is a widespread belief that the hallucinogenic effects of NANM and other benzomorphan derivatives are mediated by interactions with σ1 sites. However, NANM is also an agonist at the κ opioid receptor (KOR) and binds...

DOI: 10.1016/j.pbb.2016.05.009 Full text Dissociative Hallucinogen Kappa receptor Mice +3

Behavioral and pharmacokinetic interactions between monoamine oxidase inhibitors and the hallucinogen 5-methoxy-N,N-dimethyltryptamine.

Pharmacology, biochemistry, and behavior April 1, 2016 Adam L. Halberstadt 33 citations

Monoamine oxidase inhibitors (MAOIs) are often ingested together with tryptamine hallucinogens, but relatively little is known about the consequences of their combined use. We have shown previously that monoamine oxidase-A (MAO-A) inhibitors alter the locomotor profile of the hallucinogen 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) in rats, and enhance its interaction with 5-HT2A receptors....

DOI: 10.1016/j.pbb.2016.01.005 Full text Ayahuasca N-dimethyltryptamine Locomotor activity Modify the effects +5

Acute oral 18-methoxycoronaridine (18-MC) decreases both alcohol intake and IV nicotine self-administration in rats.

Pharmacology, biochemistry, and behavior 2016 Amir H Rezvani, Marty C Cauley, Susan Slade et al. 22 citations

The ibogaine derivative 18-methoxycoronaridine (18-MC) has been found to decrease self-administration of morphine, nicotine and alcohol in rats after systemic injection. However oral dosing is the preferred route clinically. The current study evaluated the effect of oral 18-MC dosing in rats on alcohol and nicotine self-administration. For the nicotine study, young adult female Sprague-Dawley...

DOI: 10.1016/j.pbb.2016.10.010 Full text Alcohol preferring rat Drinking Addiction treatment Alcoholism research +2

The effects of phencyclidine (PCP) on anxiety-like behavior in the elevated plus maze and the light-dark exploration test are age dependent, sexually dimorphic, and task dependent.

Pharmacology, biochemistry, and behavior November 1, 2011 Sarah M Turgeon, Daniel S. H. Kim, Melissa Pritchard et al.

Previous research in our laboratory revealed sexually dimorphic effects of prior exposure to phencyclidine (PCP) on elevated plus maze behavior. In an attempt to examine the developmental time course of this effect and determine the extent to which it generalizes to other anxiety paradigms, young adult (61-64 days old) and adult (96-107 days old) male and female rats were treated with PCP (15...

DOI: 10.1016/j.pbb.2011.08.017 Full text

Acute blockade of CB1 receptor leads to reinstatement of MDMA-induced conditioned place preference.

Pharmacology, biochemistry, and behavior November 2011 Manuel Daza‐losada, José Miñarro, María A. Aguilar et al.

Cannabis is one of the drugs most commonly consumed in combination with ecstasy (3,4-methylenedioxymethamphetamine, MDMA). Although numerous studies have attempted to further our understanding of the role of the cannabinoid system in drug abuse, few have focused on how it influences the rewarding effects of MDMA. The aim of the present study was to evaluate the role of the CB1 cannabinoid...

DOI: 10.1016/j.pbb.2011.07.011 Full text

MDMA: interactions with other psychoactive drugs.

Pharmacology, biochemistry, and behavior October 2011 Wael M.Y. Mohamed, Sami Ben Hamida, Jean-Christophe Cassel et al.

3,4-Methylenedioxymethamphetamine (MDMA, ecstasy) is one of the most widely abused illegal drugs. Some users self-report euphoria and an increased perception and feeling of closeness to others. When taken in warm environments, MDMA users may develop acute complications with potential fatal consequences. In rodents, MDMA increases locomotor activity and, depending on ambient temperature, may...

DOI: 10.1016/j.pbb.2011.06.032 Full text

Stimulus control by 5-methoxy-N,N-dimethyltryptamine in wild-type and CYP2D6-humanized mice.

Pharmacology, biochemistry, and behavior September 1, 2011 Jerrold C Winter, D J Amorosi, Kenner C Rice et al. 10 citations

In previous studies we have observed that, in comparison with wild type mice, Tg-CYP2D6 mice have increased serum levels of bufotenine [5-hydroxy-N,N-dimethyltryptamine] following the administration of 5-MeO-DMT. Furthermore, following the injection of 5-MeO-DMT, harmaline was observed to increase serum levels of bufotenine and 5-MeO-DMT in both wild-type and Tg-CYP2D6 mice. In the present...

DOI: 10.1016/j.pbb.2011.05.015 Full text Drug interaction Synergism Potentiation Enhancement +25

Influences of activity wheel access on the body temperature response to MDMA and methamphetamine.

Pharmacology, biochemistry, and behavior September 2011 N W Gilpin, M J Wright, G Dickinson et al.

Recreational ingestion of the drug 3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") can result in pathologically elevated body temperature and even death in humans. Such incidents are relatively rare which makes it difficult to identify the relative contributions of specific environmental and situational factors. Although animal models have been used to explore several aspects of...

DOI: 10.1016/j.pbb.2011.05.006 Full text

Behavioral, hyperthermic and pharmacokinetic profile of para-methoxymethamphetamine (PMMA) in rats.

Pharmacology, biochemistry, and behavior March 2011 Tomáš Páleníček, Marie Balíková, Miroslava Rohanová et al.

Despite poisoning with the ecstasy substitute para-methoxymethamphetamine (PMMA) being typically associated with severe hyperthermia and death, behavioral and toxicological data on this drug are missing. Herein we present the behavioral profile of PMMA, its hyperthermic potency and pharmacokinetic profile in rats. The effects of PMMA 5 and 20 mg/kg on locomotion, on prepulse inhibition (PPI) of...

DOI: 10.1016/j.pbb.2010.12.011 Full text

Salvinorin A fails to substitute for the discriminative stimulus effects of LSD or ketamine in Sprague-Dawley rats.

Pharmacology, biochemistry, and behavior September 1, 2010 Bryan A Killinger, Mary M Peet, Lisa E Baker 41 citations

Salvia divinorum is a small perennial shrub that has gained recent popularity among the drug-using subculture as a legal alternative to hallucinogens. Salvinorin A, the main active compound found in the S.divinorum plant, is an atypical hallucinogen with pharmacological selectivity at kappa opioid (KOP) receptor sites and is a unique non-nitrogenous neoclerodane diterpene which is structurally...

DOI: 10.1016/j.pbb.2010.05.014 Full text Salvinorin a Salvia divinorum LSD Ketamine +16

Neurophysiological and cognitive effects of smoked marijuana in frequent users.

Pharmacology, biochemistry, and behavior September 2010 Carl L. Hart, Aaron B Ilan, Alan Gevins et al.

Previously, we reported that acute marijuana intoxication minimally affected complex cognitive performance of daily marijuana smokers. It is possible that the cognitive tests used were insensitive to marijuana-related cognitive effects. In the current study, electroencephalographic (EEG) signals were recorded as daily marijuana users performed additional tests of immediate working memory and...

DOI: 10.1016/j.pbb.2010.06.003 Full text

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